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International Journal of Bioprinting 3D bioprinting for musculoskeletal system

tissue constructs, including ears and muscles, were Author contributions
successfully formed without surgical exposure. Taking Conceptualization: Qiang Wei, Yuhao Peng, Bin Li
a similar principle, Urciuolo et al. developed a new Data curation: Qiang Wei, Yuhao Peng, Weicheng Chen,
bioprinting technique, which enables direct fabrication Yudong Duan, Genglei Chu, Shujun Lyu
of functional tissues in living animals, and named it Supervision: Fengxuan Han, Bin Li
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intravital 3D bioprinting. The technique allows in Visualization: Yuhao Peng, Zhigang Chen, Weicheng
situ bioprinting of a variety of complex tissue constructs Chen, Yudong Duan, Jie Hu
such as dermis, skeletal muscle and brain.
Writing – original draft: Qiang Wei
When it comes to disease modeling, 3D bioprinting is Writing – review & editing: Qiang Wei, Fengxuan Han,
a powerful tool and has been employed to create complex Bin Li
and dynamic models of various types of tumors. The
196
emergence of bioprinted models has enhanced our Ethics approval and consent to participate
understanding of the onset and progression of disease. Not applicable.
They also provide a valuable platform for the screening
and development of therapeutic drug for MSDs. Consent for publication
However, the development of 3D bioprinting for creating
musculoskeletal disease models is still in its infancy, and Not applicable.
the number of relevant studies available for review is
limited. Most existing studies utilized simplified bioprinted Availability of data
models to screen high-throughput drugs or answer simple Not applicable.
research questions. The future of bioprinting models for
personalized therapy of MSDs may lie in the creation of References
more biomimetic in vitro disease models.
1. Khodabukus A, Guyer T, Moore AC, Stevens MM, Guldberg
6. Conclusion RE, Bursac N. Translating musculoskeletal bioengineering
into tissue regeneration therapies. Sci Transl Med.
Due to its powerful ability to instantly and accurately transform 2022;14:eabn9074.
digital images into 3D entities with biological function, 3D doi: 10.1126/scitranslmed.abn9074
bioprinting offers an advanced method for the construction 2. Cieza A, Causey K, Kamenov K, Hanson SW, Chatterji S,
of complex tissue constructs as well as drug development. Vos T. Global estimates of the need for rehabilitation based
Bioprinted tissue constructs have shown promising on the Global Burden of Disease study 2019: A systematic
performance in the studies concerning the regeneration of analysis for the Global Burden of Disease Study 2019.
musculoskeletal tissues, including bone, cartilage, skeletal Lancet. 2021;396:2006-2017.
muscle, and meniscus. Aided by the development of newly doi: 10.1016/s0140-6736(20)32340-0
synthesized materials and novel bioprinting technologies, 3. Zhang S, Xing M, Li B. Recent advances in musculoskeletal
the application of 3D bioprinting for musculoskeletal tissue local drug delivery. Acta Biomater. 2019;93:135-151.
engineering will be significantly expanded in the future. doi: 10.1016/j.actbio.2019.01.043

Acknowledgments 4. Agarwal R, Williams K, Umscheid CA, Welch WC.
Osteoinductive bone graft substitutes for lumbar
None. fusion: A systematic review. J Neurosurg Spine. 2009;11:
729-740.
Funding doi: 10.3171/2009.6.Spine08669
5. Charalambides C, Beer M, Cobb AG. Poor results after
This work was funded by the National Natural Science augmenting autograft with xenograft (Surgibone) in hip
Foundation of China (81925027, 32130059, 32171350), the revision surgery: A report of 27 cases. Acta Orthop. 2005;76:
Medical and Health Science and Technology Innovation 544-549.
Project of Suzhou (SKY2022105), and the Priority doi: 10.1080/17453670510041547
Academic Program Development of Jiangsu Higher 6. Shapira A, Dvir T. 3D tissue and organ printing—Hope and
Education Institutions. reality. Adv Sci. 2021;8:2003751.
doi: 10.1002/advs.202003751
Conflict of interest
7. Vanderburgh J, Sterling JA, Guelcher SA. 3D printing
The authors declare no conflicts of interest. of tissue engineered constructs for in vitro modeling of

Volume 10 Issue 1 (2024) 97 https://doi.org/10.36922/ijb.1037