Page 132 - IJB-10-1

International

Journal of Bioprinting

REVIEW ARTICLE
REVIEW ARTICLE
Research progress of 3D-bioprinted functional
pancreas and in vitro tumor models

LiushengWu 1,2† , Huansong Li , Yangsui Liu , Zhengyang Fan , Jingyi Xu ,
1†
4†
3†
3†
Ning Li , Xinye Qian , Zewei Lin , Xiaoqiang Li , and Jun Yan 1*
6*
1
5†
2*
1 Beijing Tsinghua Chang Gung Hospital, School of Clinical Medicine, Tsinghua University, Beijing,
China
2 Department of Thoracic Surgery, Peking University Shenzhen Hospital, Shenzhen, Guangdong,
China
3
Hepatobiliary Pancreatic Center, Xuzhou Central Hospital, Xuzhou, Jiangsu, China
4 Department of Graduate School, Xinjiang Medical University, Urumqi, Xinjiang, China
5 Graduate School of Qinghai University, Xining, Qinghai, China
6 Department of Hepatological Surgery, Peking University Shenzhen Hospital, Shenzhen,
Guangdong, China
(This article belongs to the Special Issue: Advances in Bioprinting for Medical Applications)
Abstract

† These authors contributed equally With the rapid development of three-dimensional (3D) bioprinting technology,
to this work. the research revolving around in vitro functional pancreas and tumor models
has become the focus of attention in the field of life sciences. This review
*Corresponding authors:
Zewei Lin (szlinzw@126.com) aims to summarize and deeply discuss the research progress and prospects
Xiaoqiang Li of 3D-bioprinted functional pancreas and in vitro tumor models. The efforts in
(dr.lixiaoqiang@gmail.com) improving 3D printing technology to increase its accuracy and reliability in the
Jun Yan biomedical applications have been ramped up over the past few years. Researchers
(yanjun1619@tsinghua.edu.cn) are now able to create highly complex 3D structures through precise layering
Citation: Wu L, Li H, Liu Y, et al. of biological materials at the micron scale. For instance, a functional pancreas
Research progress of 3D- can be printed in vitro by combining cells, biomaterials, and growth factors.
bioprinted functional pancreas and
in vitro tumor models. Int J Bioprint. The introduction of new technologies allows researchers to more accurately
2024;10(1):1256. simulate the growth and spread of tumors, providing a more realistic platform
doi: 10.36922/ijb.1256 for cancer treatment research. This not only helps accelerate the process of drug
Received: July 5, 2023 screening, but also lays the foundation for personalized medicine. As multiple
Accepted: September 27, 2023 disciplines, such as materials science, cell biology, and engineering, continue
Published Online: January 3, 2024
to converge with 3D bioprinting, emergence of more innovative applications is
Copyright: © 2024 Author(s). anticipated. However, despite significant progress, many technical and ethical
This is an Open Access article challenges still need to be overcome before practical clinical applications can be
distributed under the terms of the
Creative Commons Attribution implemented. In summary, the application of bioprinting technology is of great
License, permitting distribution, significance to the study of functional pancreas and in vitro tumor models, which
and reproduction in any medium, could lead to new breakthroughs in the development of clinical treatment and
provided the original work is
properly cited. personalized medicine.
Publisher’s Note: AccScience
Publishing remains neutral with Keywords: 3D bioprinting technology; In vitro functional pancreatic model; In vitro
regard to jurisdictional claims in
published maps and institutional pancreatic cancer model; Artificial intelligence programming technology
affiliations.

Volume 10 Issue 1 (2024) 124 https://doi.org/10.36922/ijb.1256