Page 36 - IJB-2-2
P. 36
Bioprinting in cardiovascular tissue engineering: a review
Figure 3. Future prospect of cardiac tissue engineering using bioprinting.
onto cardiac patches to enhance electrical properties
of engineered cardiac construct [84,85] . Hydrogel’s arch- References
itecture and microenvironment can be tuned to illicit 1. Braunwald E, 2013, Heart failure. JACC: Heart Failure,
certain cellular response [86,87] . Oxygen-rich hydrogel vol.1(1): 1–20.
can be engineered to sustain high metabolic demand of http://dx.doi.org/10.1016/j.jchf.2012.10.002
engineered cardiac tissue before angiogenesis occ- 2. Go A S, Mozaffarian D, Roger V L, et al., 2014, Heart
urs [88,89] . disease and stroke statistics—2014 update: a report from
the American Heart Association. Circulation, vol.129:
4. Conclusion e28–e292.
http://dx.doi.org/10.1161/01.cir.0000441139.02102.80
Bioprinting remains as a powerful tool for engineers 3. Adler C P, Friedburg H, Herget G W, et al., 1996, Varia-
and scientists to produce engineered biological con- bility of cardiomyocyte DNA content, ploidy level and
struct from virtual designs. Future engineered cardi- nuclear number in mammalian hearts. Virchows Archiv,
ovascular tissue will see an integration of lessons vol.429: 159–164.
learnt from decade of cardiovascular tissue engineer- http://dx.doi.org/10.1007/bf00192438
ing and precision from bioprinting, to print constructs 4. Laflamme M A and Murry C E, 2011, Heart regenera-
with close resemblance of a native myocardium. In tion. Nature, vol.473: 326–335.
essence, bioprinting serve as a platform to provide http://dx.doi.org/10.1038/nature10147
macro and microscale engineering while engineering 5. Hunter P, 2009, Cardiovascular mechanics, in Binder M,
material formulation and cell biology to initiate na- Hirokawa N and Windhorst U (eds), Encyclopedia of
noscale responses — bringing about an engineered myo- Neuroscience, Springer, Berlin Heidelberg, 564–567.
http://dx.doi.org/10.1007/978-3-540-29678-2_824
cardium with multiscale resemblance of native tissue.
6. Ferreira F P, Kilner P J, McGill L A, et al., In vivo car-
Conflict of Interest and Funding diovascular magnetic resonance diffusion tensor imag-
ing shows evidence of abnormal myocardial laminar
The authors declare no conflict of interest. orientations and mobility in hypertrophic cardiomyopa-
32 International Journal of Bioprinting (2016)–Volume 2, Issue 2

