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International Journal of Bioprinting Advancements in 3D printing

viability and utilizing biofeedback mechanisms to can interact with surrounding tissues. Addressing
guide cell differentiation. issues related to structural stability and interaction is
crucial.
(ii) Structural complexity. Creating biologically complex
tissues is a challenge. Using multi-material printing 6.6. Artificial food
and scaffold melting techniques can enable the 3D-printed artificial food is a field full of potential, offering
fabrication of more intricate structures. many opportunities, but this rising domain also faces some
(iii) Biocompatibility. Printed materials must be challenges. The following are the future prospects and
compatible with the human body and not trigger challenges of 3D-printed artificial food.
immune responses. Researchers have been developing 3D-printed food can be customized according to
novel bioinks to enhance biocompatibility. individual health needs and taste preferences, providing

(iv) Functionality. Structured biological tissues must more personalized nutritional solutions. A more efficient
perform specific physiological functions. This may production process is employed to produce 3D-printed
require consideration of the tissue’s microstructure food, thereby reducing food waste and the demand for
and tissue engineering parameters during the design land and water resources. This technology can be used to
create new food textures, shapes, and tastes, driving food
process to ensure it possesses the desired functionality.
innovation. 3D printing of food is regarded as a rapid food
6.5. Embedded bioprinting production process that can efficiently overcome any food
Embedded 3D bioprinting refers to the 3D printing shortage situations.
technology where biological materials are directly However, there are still some challenges facing this
embedded into living tissues to repair, enhance, or particular segment of 3D printing. Developing materials
augment the functionality of biological organisms. This suitable for 3D printing of food while considering food
is a field with enormous potential but also faces future safety, taste, and texture is a complex challenge. Ensuring
opportunities and challenges. the safety of 3D-printed food is a critical issue that needs

Embedded 3D bioprinting enables the customization to be addressed by a strict adherence to the prevailing
of biological tissues and organs according to the food manufacturing and hygiene standards. Currently, 3D
individual patient’s needs, epitomizing the concept of printing of food is a relatively costly endeavor; therefore,
personalized medicine. This technology can be used for improvements in production efficiency to reduce costs
tissue repair, organ regeneration, and treatment of various and achieve scalability are required. In addition, the use
diseases and injuries. Embedded 3D bioprinting can also of sustainable materials and production methods must be
be employed to create microtissue models with specific considered to minimize the environmental impact arising
cell types and functions, suitable for drug screening and from the 3D printing process of food.
disease research. Devices for embedded 3D bioprinting
can be utilized to produce wearable sensors, implantable 7. Conclusion
medical devices, and smart health monitoring systems. If In summary, 3D bioprinting technology is widely used
successful, embedded 3D bioprinting holds the potential in the medical field and has unique advantages in the
to address long-standing issues in the medical field, such field of organ reconstruction, including the production of
as organ transplantation. simulated medical models and biomedical devices. This
technique has garnered enormous attention, which has
However, it also presents several challenges:
promoted the unprecedented development of a growing
(i) Material selection and compatibility. The biological number of promising biomolecular materials. At present,
materials used in printing must be compatible 3D bioprinting technology is still unable to build organs
with the host tissue to prevent immune rejection. and tissues that can be directly used for transplantation.
Nevertheless, finding suitable bioinks and scaffold In fact, several challenges should be surmounted in
materials remains a challenge. the process of continuously optimizing the current
bioprinting techniques, such as strengthening immune
(ii) Cell survival and differentiation. During the response, affording capacity to vascularize, enabling
embedding process, cells need to survive and adapt multi-tissue printing, and allowing bionic structure
to their new environment. However, ensuring cell formation, which are also viewed as opportunities for
survival and differentiation is a complex issue.
further improving the techniques. We believe that in
(iii) Structural stability. The structures created through the near future, bioprinting can achieve more profound
embedded 3D bioprinting must remain stable and breakthroughs in artificial organ preparation, which

Volume 10 Issue 2 (2024) 72 doi: 10.36922/ijb.1752