Page 301 - IJB-10-3

International Journal of Bioprinting Design and optimization of 3DP bioscaffolds

Figure 10. Impact of geometric dimensions on the performance of scaffolds. Panels a, b, and c depict the effect of diameter variations on the average oxygen
concentration, cell density, and cell count, respectively, with a fixed thickness of 1.5 mm. Panels d, e, and f show the influence of thickness variations on the
average oxygen concentration, cell density, and cell count, respectively, with a diameter of 4 mm.

The effects of initial material porosity (ε) on average via convection and diffusion. It is feasible to modulate
44
oxygen concentration and cell density are presented in the porosity by tuning the concentration or molecular
Figure 11b and f. Increasing the material porosity can weight of the hydrogel materials. As expected, a higher
significantly promote the oxygen concentration in the value of the maximum oxygen uptake rate (V) led to faster
r
scaffold due to the enhanced diffusion. The percentage on oxygen consumption, resulting in a significant reduction
day 7 was raised from approximately 10% to 70% when in oxygen concentration as well as cell density (Figure
increasing the porosity from 0.3 to 0.9. Accordingly, the 11c and g). Similarly, the actual maximum cell growth
cell proliferation was improved by ~3 times (see Figure rate (μ ) greatly impacts the average oxygen concentration
r
11f). Materials with high porosity not only offer adequate and cell density (Figure 11d and h). V and μ are cell-
r
r
space for cell interaction and thus facilitate intercellular type-dependent and vary among different types of cells,
signaling, but also enhance nutrient and waste transport suggesting that an optimized scaffold for a specific type
Volume 10 Issue 3 (2024) 293 doi: 10.36922/ijb.1838