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International Journal of Bioprinting Design and optimization of 3DP bioscaffolds

(a) (e)

(b) (f)

(c) (g)

(d) (h)

Figure 11. Sensitivity of average oxygen concentration to parameters including (a) initial cell density, (b) initial porosity, (c) maximum oxygen absorption
rate, and (d) maximum cell growth rate. Panels e to h depict the sensitivity of average cell density to the same parameters aforementioned.

of cell may not be suitable for another cell type, and re- optimized based on the parameters in this study may not
designing and optimization are thus needed. For example, be suitable for tumor cell growth.
tumor cells easily aggregate into balls, and its growth trend These results indicated that initial material porosity,
is completely different from that of C2C12, so the structure initial cell density, maximum oxygen uptake rate,

Volume 10 Issue 3 (2024) 294 doi: 10.36922/ijb.1838