Page 69 - IJB-10-3

International

Journal of Bioprinting

REVIEW ARTICLE
The promising applications of 3D printing

technology in neurotrauma

Wenbo He 1,2† , Chongxi Xu 1,2† , Wenbi Wu Yuchen Chen , Jingxuan Hou ,
3†
2
2
,
Zhouhaoran Chen , Jianguo Xu , Maling Gou *, and Yu Hu *
1
2
1
3
1 Department of Neurosurgery, West China Hospital, Chengdu, Sichuan, China
2 West China School of Medicine, Sichuan University, Chengdu, Sichuan, China
3 Department of Biotherapy, Cancer Center and State Key Laboratory of Biotherapy, West China
Hospital, Sichuan University, Chengdu, Sichuan, China
Abstract
Neurotrauma mainly includes brain injury, spinal cord injury, and peripheral nerve
injury, which are characterized by high morbidity and disability rates, and involve
costly treatments. Currently, various strategies have been applied for the treatment of
neurotrauma, but their efficacy is unsatisfactory. New effective strategies are needed
to be developed to promote recovery after neurotrauma. In recent years, three-
dimensional (3D) printing technology has been used to manufacture customized
and complex constructs in tissue engineering applications, exhibiting great potential
in repairing nervous system injuries. In this review, we introduce the principles
and advantages of 3D printing and 3D bioprinting technologies that have been
† These authors contributed equally applied to repair injured nervous system. In particular, we summarize the current
to this work.
strategies in the aspects of biomaterials, physical stimulation, bioactive substances,
*Corresponding authors: cell transplantation, and their combination that have been considered in fabricating
Yu Hu
(huyu0304@scu.edu.cn) 3D-printed devices for neurotrauma treatment. Additionally, the challenges and
Maling Gou prospects of 3D printing for neurotrauma treatment were also presented.
(goumaling@scu.edu.cn)
Citation: He W, Xu C, Wu W, et al. Keywords: Neurotrauma; Traumatic brain injury; Spinal cord injury; Peripheral nerve
The promising applications of 3D injury; Bioprinting; Neural tissue regeneration
printing technology in neurotrauma.
Int J Bioprint. 2024;10(3):2311.
doi: 10.36922/ijb.2311
Received: November 24, 2023
Accepted: January 15, 2024 1. Introduction to neurotrauma and three-dimensional
Published Online: February 12, 2024 (3D) printing
Copyright: © 2024 Author(s).
This is an Open Access article 1.1. Components of nervous system
distributed under the terms of the The nervous system consists of the central nervous system (CNS) and the peripheral
Creative Commons Attribution nervous system (PNS). The brain and spinal cord are the main components of the CNS.
1
License, permitting distribution,
and reproduction in any medium, The cerebrum, diencephalon, cerebellum, and brainstem are the four major regions of
provided the original work is the brain, which are in charge of a series of fundamental and higher functions, such
properly cited. as sensorimotor, cognitive, memory, and emotion. The spinal cord is located within
Publisher’s Note: AccScience the spinal canal and consists of white and gray matter, serving as a connection for
Publishing remains neutral with transferring information between the brain and the PNS. The PNS mainly comprises
2
regard to jurisdictional claims in
published maps and institutional afferent sensory fibers and efferent motor fibers, which control the body movement,
3
affiliations. conduct sensation, and regulate internal organ homeostasis.

Volume 10 Issue 3 (2024) 61 doi: 10.36922/ijb.2311