Page 36 - IJB-10-4

International

Journal of Bioprinting

REVIEW ARTICLE
3D bioprinting in otorhinolaryngology: from

bench to clinical application

Yuming Zhang , Qian Yang , Hua Wan , Gangcai Zhu , Zian Xiao , Ying Zhang ,
1
1
2
1
1
1
Lanjie Lei *, and Shisheng Li *
1
3
1 Department of Otorhinolaryngology-Head and Neck Surgery, Second Xiangya Hospital, Central
South University, Changsha, Hunan, China
2 Department of Otorhinolaryngology-Head and Neck Surgery, Zhuzhou 331 Hospital, Zhuzhou,
Hunan, China
3
Key Laboratory of Artificial Organs and Computational Medicine in Zhejiang Province, Institute of
Translational Medicine, Zhejiang Shuren University, Hangzhou, Zhejiang, China
(This article belongs to the Special Issue: Innovative Tissue and Diseases Models - Novelties in Bioprinting/3D
Bioprinting)
Abstract

Three-dimensional (3D) bioprinting is a promising additive manufacturing
technology that uses imaging data and computer-assisted deposition of biological
materials or cells to reconstruct complex 3D structures accurately. This technology
has progressed rapidly, in part because of its integration across multiple disciplines
and combination with other technologies for clinical applications. Advances in
experimental research and clinical applications related to otorhinolaryngology
*Corresponding authors: have led to the development of diagnostic and treatment methods based on 3D
Lanjie Lei
(lanjielei2023@zjsru.edu.cn) bioprinting, including the development of tissue engineering scaffolds, biosensors,
Shisheng Li organ chips, and organoids, surgical planning, graft construction, and medical
(lissdoctor@csu.edu.cn) education. Additionally, otorhinolaryngologists will be better equipped to treat
Citation: Zhang Y, Yang Q, tissue function defects with personalized printed graft implants. It is also expected
Wan H, et al. 3D bioprinting in that 3D printing can be used to build ideal in vitro models in the future to help
otorhinolaryngology: from bench to solve existing research challenges. This article briefly introduces the relevant 3D
clinical application.
Int J Bioprint. 2024;10(4):3006. bioprinting technologies and bioinks that can be used by otorhinolaryngologists
doi: 10.36922/ijb.3006 and discusses their potential applications in otorhinolaryngology.
Received: February 24, 2024
Accepted: March 14, 2024 Keywords: 3D bioprinting; Otorhinolaryngology; Tissue engineering; Experimental
Published Online: April 29, 2024
research; Clinical application
Copyright: © 2024 Author(s).
This is an Open Access article
distributed under the terms of the
Creative Commons Attribution
License, permitting distribution, 1. Introduction
and reproduction in any medium,
provided the original work is Otorhinolaryngology is a complex subject that involves multiple organs and tissues,
properly cited. such as the ear, nose, throat, and trachea. These organs have many specialized functions,
1
Publisher’s Note: AccScience including those related to breathing, speaking, and facial animation. Serious flaws
Publishing remains neutral with in these organs can result in their decline or loss of function, negatively affecting
regard to jurisdictional claims in
2
published maps and institutional the patient’s quality of life and inducing life-threatening consequences. Ossicular
affiliations. destruction caused by cholesteatoma, a major ear disease, is currently one of the leading

Volume 10 Issue 4 (2024) 28 doi: 10.36922/ijb.3006