Page 111 - IJB-5-2
P. 111
Lenoir L, et al.
Therefore, to reach the objective of flow experiment References
in carotid, molding technique, and cells resistance under
high shear stress must be improved. 1. Lorec A, 2017, Un Vecteur Made in CEA Contre la
Drépanocytose. Les Défis Du Cea, 24(213):8-9.
6. Conclusion and Future Work 2. Rees DC, Williams TN, Gladwin MT, 2010, Sickle-
In this paper, a global framework of design approach cell Disease. Lancet, 376(9757):2018-31. DOI 10.1016/
focused on AM to develop vascular geometry is proposed. S0140-6736(10)61029-X.
It can be applied to all human-based products designed 3. Roseff SD, 2009, Sickle Cell Disease: A Review.
for biological purposes using AM. The main research Immunohematol J Blood Group Serol Educ, 25(2):67-74.
question of this article is: Which methodology should be
used to develop an AM vascular geometry designed for 4. GBD, 2015, Mortality and Causes of Death Collaborators 2016,
cell culture in these in vitro models? Global, Regional, and National Life Expectancy, All-cause
The proposed AM-Biopart methodology takes Mortality, and Cause-specific Mortality for 249 Causes of
place in four stages with initialization, concept and Death, 1980-2015: A Systematic Analysis for the Global
feasibility, design and development, and finally Burden of Disease Study 2015. Lancet, 388(10053):1459-544.
validation and optimization. This allows us to have a DOI 10.1016/S0140-6736(16)31012-1.
common thread for people wishing to achieve vascular
geometry in AM, with the collaboration of different 5. National Heart, Lung and Blood Institute, 2016, How is
trades. The proposed method has been successfully Sickle Cell Disease Treated? Amended; 2017. Available
applied to the design of a carotid artery. However, for from: https://www.nhlbi.nih.gov/health-topics/sickle-cell-
later if we want to guarantee a fully optimized part, disease. [Last accessed on 2019 May 24].
some process parameters, such as the choice of laser 6. Hagedorn TJ, Grosse IR, Krishnamurty S, 2015, A Concept
power, scanning speed, and hatch spacing, must be Ideation Framework for Medical Device Design. J Biomed
taken into account in the process. Future work will Inform, 55:218-30. DOI 10.1016/j.jbi.2015.04.010.
involve testing the proposed methodology on a more
complex case study. 7. Arntzen-Bechina A, Leguy C, 2007, A Model of Knowledge
Sharing in Biomedical Engineering: Challenges and
Conflicts of Interest Requirements. J Bus Chem, 4(1):27-43.
No potential conflicts of interest were reported by the 8. Wong KK, Tu JY, Sun Z, et al., 2013, Methods in Research
authors. and Development of Biomedical Devices. Singapore: World
Scientific Publishing Co.
Authors’ Contributions
9. Bradbury TJ, Gaylo CM, Fairweather JA, et al., 2004, System
Laurène Lenoir is an engineering student at Arts et and Method for Rapidly Customizing Design, Manufacture
Metiers Paristech School of Engineering in Paris, France and/or Selection of Biomedical Devices. U.S. Patent Number
and in a double degree of master research Innovation and 6772026.
Design at Product Design and Innovation Laboratory
(LCPI). 10. Chu C, Graf G, Rosen DW, 2008, Design for Additive
Frédéric Segonds is Associate Professor of Mechanical Manufacturing of Cellular Structures. Comput Aided Des
Engineering at Arts et Metiers ParisTech School of Appl, 5(5):686-96.
Engineering in Paris, France, and member of the Product 11. Bourell DL, Beaman JB, Leu MC, et al., 2009, A Brief
Design and Innovation Laboratory (LCPI). His research History of Additive Manufacturing and the 2009 Roadmap
interests focus on product lifecycle management, for Additive Manufacturing: Looking Back and Looking
early stages of design collaboration optimization and
Creativity and Design With/For Additive Manufacturing Ahead. In: Proceedings of the US-Turkey Workshop on Rapid
(DWAM/DFAM). Technologies, pp. 24-25.
Pablo Bartolucci, MD, PhD is full Professor in 12. Gibson I, Rosen D, Stucker B, 2015, Additive Manufacturing
medicine at French Sickle Cell Referent Center – Henri Technologies: 3D Printing, Rapid Prototyping, and
Mondor hospital, and leader of research group (Mondor Direct Digital Manufacturing. New York: Springer.
Institute Biomedical research, INSERM U955 IMRB- DOI 10.1007/978-1-4939-2113-3.
team 2)
Kim-Anh Nguyen MD, PhD is a researcher at Imagine 13. Rosen DW, 2007, Computer-Aided Design for Additive
Institute and French Blood Establishment, Mondor Manufacturing of Cellular Structures. Comput Aided Des
Institute Biomedical research, INSERM U955-team 2. Appl, 4(5):585-94.
International Journal of Bioprinting (2019)–Volume 5, Issue 2 107

