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RESEARCH ARTICLE

The mussel-inspired assisted apatite mineralized on

PolyJet material for artificial bone scaffold

Yi-Wen Chen 1,2† , Hsin-Yuan Fang 1,3,4† , Ming-You Shie , Yu-Fang Shen *
6,7
1,5
1 Three-dimensional Printing Medical Research Center, China Medical University Hospital, China Medical University,
Taichung, Taiwan
2 Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan
3 Department of Thoracic Surgery, China Medical University Hospital, Taichung, Taiwan
4 School of Medicine, China Medical University, Taichung, Taiwan
5 School of Dentistry, China Medical University, Taichung, Taiwan
6 Three-dimensional Printing Medical Research Institute, Asia University, Taichung, Taiwan
7 Department of Bioinformatics and Medical Engineering, Asia University, Taichung, Taiwan
† These authors contributed equally to this work.

Abstract: With the development of three-dimensional (3D) printing, many commercial 3D printing materials have been applied
in the fields of biomedicine and medical. MED610 is a clear, biocompatible PolyJet material that is medically certified for
bodily contact. In this study, the polydopamine (PDA)/hydroxyapatite (HA) coating was added to the printed MED610 objects
to evaluate its physical properties, cell proliferation, cell morphology, and alkaline phosphatase expression level. The results
show that the PDA/HA coating helps printed objects to enhance the hardness, biocompatibility, and osteogenic differentiation
potential. We expect that PDA/HA coatings contribute to the applicability of MED610 in biomedical and medical applications.
Keywords: Three-dimensional printing; Polydopamine; Hydroxyapatite; MED610; Osteogenic differentiation; PolyJet
technology

*Correspondence to: Yu-Fang Shen, Three-dimensional Printing Medical Research Institute, Asia University, Taichung 41354, Taiwan;
cherryuf@gmail.com
Received: April 10, 2019; Accepted: May 27, 2019; Published Online: July 11, 2019

Citation: Chen Y, Fang H, Shie M, et al., 2019, The mussel-inspired assisted apatite mineralized on PolyJet material for
artificial bone scaffold. Int J Bioprint, 5(2): 197. http://dx.doi.org/10.18063/ijb.v5i2.197

1. Introduction can be used to create customized and mechanical aids
to restore patient’s physical control and action. Cases:
With the development of multidetector computed Arthrogryposis multiplex congenital and paralyzed
tomography and magnetic resonance imaging (MRI), the patients . Advantages: The small number of customized
[2]
three-dimensional (3D) structure of the patient’s body can products can be manufactured. (2) The development of the
be presented by these medical imaging techniques and customized implant molds: The required and customized
computer-aided software engineering. The 3D structures metal or silicone implants can be fabricated through the
can be converted to the interpreted surface tessellation molds which are obtained by the 3D printed patient’s
language files for 3D printing by the computer software desired polymer implant models [3,4] . (3) The pre-operative
processing. Therefore, the 3D printing technology in 3D model: By 3D printing of patient’s tissue models, the
[1]
modern medicine has great development in current years . more complicated or high-risk surgery can be planned
The events of 3D printing applied in current medical in advance and the time of surgery can be shortened to
practice were shown below: (1) The manufacturing of decrease the surgical risk . In addition, 3D printing
[4]
in vitro mechanical aids: The 3D printing technology model can also facilitate the improvement of commercial
The mussel-inspired assisted apatite mineralized on PolyJet material for artificial bone scaffold.© 2019 Chen, et al. This is an Open Access article distributed
under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), permitting
all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
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