Page 105 - IJB-10-5

International

Journal of Bioprinting

REVIEW ARTICLE
Advancements in 3D bioprinting for precision

medicine: Enhancing patient-derived organoids
and extracellular vesicle applications in

inflammatory diseases

Hyun Sung Park † id , Jae Han Park † id , Mi-Kyung Oh* , and Kyung-Rok Yu* id
id
Department of Agricultural Biotechnology and Research Institute of Agriculture and Life Science,
Seoul National University, Seoul, Republic of Korea
(This article belongs to the Special Issue: The latest advancements in bioprinting technology)

Abstract

The integration of three-dimensional (3D) bioprinting with cultures of patient-
derived organoids represents a transformative advancement in precision medicine,
enabling the creation of anatomically accurate and physiologically relevant tissue
models. These models are pivotal for personalized disease modeling, therapeutic
development, and regenerative medicine. 3D bioprinting enhances the structural
and functional fidelity of organoids, thereby improving their application in drug
screening and disease intervention strategies. Additionally, this technology facilitates
† These authors contributed equally the study of extracellular vesicles (EVs) released from patient-derived organoids,
to this work.
which are rich in bioactive molecules and play crucial roles in modulating immune
*Corresponding authors: responses. Particularly in chronic inflammatory conditions, these organoid-derived
Mi-Kyung Oh (ipomk@snu.ac.kr) EVs are instrumental in cellular communication and improve our understanding of
Kyung-Rok Yu (cellyu@snu.ac.kr)

disease mechanisms beyond traditional biopsies. This review focuses on the latest
Citation: Park HS, Park JH, developments in 3D bioprinting techniques for organoids and EVs, highlighting
Oh M-K, Yu K-R. Advancements their potential to revolutionize the treatment of inflammatory diseases through
in 3D bioprinting for precision
medicine: enhancing patient- precision medicine.
derived organoids and
extracellular vesicle applications in
inflammatory diseases. Keywords: 3D bioprinting; Patient-derived organoids; Extracellular vesicles;
Int J Bioprint. 2024;10(5):4054. Immune-mediated chronic diseases; Personalized medicine
doi: 10.36922/ijb.4054
Received: June 27, 2024
Revised: July 23, 2024
Accepted: July 25, 2024
Published Online: July 30, 2024 1. Introduction
Copyright: © 2024 Author(s). Chronic inflammatory diseases, such as rheumatoid arthritis (RA), inflammatory bowel
This is an Open Access article disease (IBD), and neuroinflammation, are complex medical conditions characterized
distributed under the terms of the
1,2
Creative Commons Attribution by persistent inflammation and tissue damage. The pathophysiology of these diseases
License, permitting distribution, involves a combination of genetic, environmental, and immunological factors that result
and reproduction in any medium, in varying patient responses to standard treatments, necessitating a more personalized
provided the original work is
properly cited. treatment approach.
Publisher’s Note: AccScience In recent years, the integration of three-dimensional (3D) bioprinting technologies
Publishing remains neutral with with patient-derived organoids (PDOs) has transformed precision medicine by enabling
regard to jurisdictional claims in
published maps and institutional the development of personalized disease models and advancing therapeutic research.
affiliations. Organoids, miniaturized versions of organs grown in vitro, have shown immense

Volume 10 Issue 5 (2024) 97 doi: 10.36922/ijb.4054