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Software for bioprinting
           potential  for therapy in clinical  application  that   4.1 Printer control software
           will be minimally invasive.
             Multiple  materials  usually are  integrated  into   Most of the current existing software are for the
           medical biomaterials that are used in 3D printing   bioprinting process controlling such as graphical
           to achieve complex functions in printed objects.    user  interfaces  (GUI)-based  control  software
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           New equipment  to  guarantee  high  porosity,       like Bioscaffolder from GeSim company . This
           dimensional precision, and other useful properties   software works with StereoLithography  (STL)
           could be developed  in the future.  There  is also   files  representing  object  surface.  It  has  two
           a  need  to  study  high-performance  materials  for   modules: Scaffold-generator  and STL-interface.
           various medical-oriented 3D printing techniques.    The Organovo company for their NovoGen MMX
                                                               Bioprinter developed a general software that only
             For all applications in the field of 3D bioprinting
           described  above,  multi-component  compatible      includes  essential  functions.  It  has a  graphical
           materials must be used. A combination of materials   interface  for designing various 3D constructs.
           should  lead  to  maximum  fitness  according  to   It  allows a  user to  choose  parameters  such as
                                                               materials, cell types, printing speed, and write and
           specified parameters.                               load pre-defined commands for realizing specific
             A number of issues in the field of bioprinting
           are similar to problems that are already solvable   movements  of the robot and deposition  heads.
           by additive technologies and manufacturing.         Now,  Organovo  collaborates  with  Autodesk  to
                                                                                                            [44]
           Therefore, it would be a perspective solution       develop  controlling  software  for bioprinters .
                                                               EnvisionTEC company has developed a computer-
           to use the experience that was previously           aided design and computer-aided manufacturing
           gained in the field of multi-material 3D printing   (CAD-CAM)  software  with  a  user-friendly
           with necessary adaptation for the bioprinting.      graphical interface for its 3D-Bioplotter system.
           Summarizing all the above, studying multi-          This software has been designed to monitor and
           material 3D printing and developing new             control the printing process until it is completed.
           approaches in this research field represent one of   Fujifilm  Holdings  Corporation  Ltd.  developed  a
           the critical elements that will make progress in    GUI application software for its Dimatix Materials
           the field of bioprinting.                           Printer. This software works with bitmap files by
             Bioprinting research field could be subdivided    importing them as CAD  models and allows the
           into  the biology, materials,  and computer         conversion to bitmap format.
           engineering. We will  focus our attention  on the     CELLINK designed their own software package
           third subdivision.                                  named  HeartOS,  DNA  Cloud,  and  DNA  Studio
             In the field of multimaterial printing for both   to control the bioprinting process. It is for fast
           bioprinting and additive technologies, the creation   droplet layer-by-layer printing, where the model
           of  the  mathematical  and  computational  model    in the G-code or the STL format could be loaded.
           represents one of the critical tasks.  To produce   The software package is user-friendly and does
           a  perfect  model  in  this  field,  it  is  necessary  to   not force users to spend their time on learning the
           choose or create  software that  meets  all  model   process. The software allows the user to simply
           requirements.                                       adjust parameters such as flow and speed . The
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           4 Software for bioprinting                          software enables the user to preview a model
                                                               before printing, to perform slicing preview to see
           The computational  model is a crucial  point in     how each layer setting will affect the results and to
           bioprinting technology. It is the first issue that must   use active tools for printing infill.
           be solved when there is a task in creating some       Allevi developed the Allevi BioPrint Pro control
           living tissue or whole organ using bioprinting.     software for bioprinting . It runs online, which
                                                                                      [46]
           Nonetheless, the software development still lags    allows user to work with it from any computer.
           behind than the advancement of bioprinting .        Allevi BioPrint Pro has built-in-model generation,
                                                     [42]
           44                          International Journal of Bioprinting (2020)–Volume 6, Issue 3
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