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Pakhomova, et al.
project-based workflow, and integrated slicing. was created based on the CAD environment.
Besides, the software supplies cutting-edge This software, as many described above, is
visualization features and interface to allow users produced for the fabrication process control. In
to view and fix potential problems in their projects this software, parameters such as deposition linear
before printing. speed, toolpath deposition, syringe plunger rate in
RegenHU Ltd. is an innovative biomedical the displacement heads, and air pressure can be
company that developed three specialized altered flexibly.
software for bioprinting which represents as a
“bioprinting software suite” [43,44] . BIOCAD serves 4.2 Software for pre-processing
as a user-friendly drawing suite to design scaffolds
or tissues within minutes from scratch. BIOCAM 4.2.1 Software for operations with G-code
is the user-friendly toolpath generator and slicer According to Gulyas et al. , specialized software
[42]
of STL files for 3D models for RegenHu’s tools to control bioprinter hardware that fulfilled
bioprinters. This software allows the user to create the bioprinting requirements was developed.
multimaterial tissues that are based on digital Typically, it represents a package of open-source
3D models obtained from 3D scanners or CAD software tools that allow the users to specify the
systems or medical images. BIOCUT is a user- machine movements precisely with the help of
friendly Digital Imaging and Communications high-level programming languages. Besides, it
in Medicine (DICOM) viewer with analyzation enables us to distribute the machine movements
tools integrated into RegenHu’s bioprinting digital
workflow. Using this software, complex tissue easily across the batch of dishes of tissue culture.
structures can be created from medical images in The software is useful in applications for printing
the DICOM file format into multi-tissue modeling of living cells and printing of extracellular
and multimaterial interface for bioprinting. This matrices. The software can represent movements
software suite had been developed to explore of the machine or elements of the gCode with
the comprehensive potential of the 3DDiscover simple functions of a high-level programming
Evolution RegenHU’s bioprinter. In summary, language such as C# or Python. It includes
the RegenHU’s software suite for bioprinting can gCodeAPI.NET, gCode Editor, and PetriPrintes as
works with STL and DICOM file formats and a graphic user interface. PetriPrinter allows a user
allows user to slice 3D models that are generated in to distribute printer movements into several culture
STL. This software suite acts as a bridge between dishes that organized in a grid pattern, which is
medical and bioprinting field. However, it still defined programmatically. As for bath printing,
works with STL which is time-consuming and PetriPrinter distributes gCode objects into several
difficult approach for complicated multimaterial dishes of the culture. PetriPrinter represents a
objects such as heterogeneous living organs. In gCode generator and provides collision-safe and
addition, they had developed two instruments for optimized entry, movement between the dishes,
the bioprinting: BioFactory and 3D Discovery, and exit. Furthermore, this application can be
and the Windows-based Human Machine interface adjusted to different hardware platforms using
software to control it. settings such as start height, printing temperature,
Digilab company has developed CellJet printer row, or column distance. Besides PetriPrinter,
and Windows-based control software for the printer. there is second graphic interface known as gCode
The software is named Axsys, and automates Editor. It was developed to visualize gCode from
low volume liquid handling applications . It third-party slicer applications such as Cura or
[43]
is user-friendly and provides a user to program Slic3r and allows for manual modification and
protocols for printing with a graphical format. The optimization for utilization in the cell culture.
nSсrypt company developed printers equipped Unlike general slicers that do not offer detailed
with the computer-aided biology technology that control over the tool movements, gCode Editor

International Journal of Bioprinting (2020)–Volume 6, Issue 3 45