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Pakhomova, et al.
of control software tools fot bioprinting is more integration, analysis, control, and visualization.
widespread nowadays, in comparison with The general control software tools are represented
software tools for providing the information of as Real-time Web-based SCADA Software: Batch
shape changes during the process. In the future, Expert+. It allows user to manage all bioreactors
new bioprinters are prefer to have an integrated in one place to get intelligent alarming, store live
computational framework that should include and historical data together in history, and improve
software modules for modeling and simulation process, yield, and production.
of pre-printing and post-printing stages, and are LAMBDA laboratory provides two control
compatible with medical image data [118] . Therefore, software tools, FNet and SIAM, for the control
to prevent existing bioprinting software becomes of cell cultures and fermentation in MINIFOR
hurdles in their research field, it is necessary to fermentor and bioreactor [122,123] . FNet can control
develop new software tools that are specialized common cultures and up to 6 MINIFOR bioreactors
and able to meet all bioprinting requirements. with limited options. SIAM has better functions,
The next step after printing of the organ is a including able to control up to 99 bioreactors and
crucial stage where maturation of the organs takes offers extended functions. Both software tools
place in bioreactor. At this step, the growth and provide graphical visualization.
maturation of the bioproduct occurs. Bioreactors BioProcess by Eppendorf Inc provides three
are necessary for the acceleration of the tissue BioCommand software packages for fermentors
maturation which control the mechanical, electrical, and bioreactors [124] . BioCommand provides tools
and biochemical conditions [119] . Bioreactors needed for research, optimization, and security
act as a crucial environment in maintaining of trials. BioCommand Track and Trend is useful
the viability of the engineered tissue. Besides, for essential laboratory management and offers
bioreactors are useful for experiments and cells full monitoring and historical record-keeping
maturation processes monitoring. Although the capabilities with control of set-points and trends
bioprinting and bioproduct maturation steps are visualization. BioCommand Batch Control
separated steps, it is worth mentioning some of includes all features of the previous one but
the bioreactors control software. In the future, also allows us to perform equipment lock-out,
bioprinting and bioreactor may be able to integrate programming capability, and has a customize
as one complicated device, but it still remains a synoptic display. It is useful for optimization
task for future development . and control for the process. BioCommand
[79]
According to the Burdge and Libourel [120] , there Batch Control Plus adds three levels of security,
is an open-source software based on LabVIEW including operator, supervisor, and administrator.
that was developed for the sophisticated control It provides event logs, audit trails, and a database
of environments of the culture. This software structure. Besides, this software allows user to
uses Python for protocols and allows user to have powerful control capabilities.
control parameters of the process. LabVIEW also According to Dernowsek et al. , omics
[79]
provides an interface for monitoring the process, technologies in integration with data science,
logging of data, and creating a protocol to execute machine learning, and other intelligent tools will
user-defined protocols. ILS automation provides a contribute to a new field known as “computational
bioreactor control system that includes specialized biology in the 4.0 industry.” Integration platforms
bioreactors integrated with control systems for cell that consist of these fields are known as
culture systems, fermentation systems, biofluel biofabrication lines. Biofabrication line consists of a
systems, and two separate software tools as system set of devices that could produce all necessary types
integration and control software tools [121] . of models: mathematical, physical, and biological,
Ignition Scada Integrator is a system integration keeping the necessary spatial distribution. It is
software tools. It is an all-in-one software presumed that biofabrication lines will be common
solution that provides user with unparalleled data in the future . The current computational biology
[79]
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