Page 162 - IJB-10-6

International

Journal of Bioprinting

REVIEW ARTICLE
Comprehensive insight into 3D bioprinting

technology for brain tumor modeling

Ayoung Kim 1,2† id , Kyumin Mo 1,2† id , Soohyun Choe 1,2† id , Miyoung Shin 3 id ,
and Hyunho Yoon *
1,2 id
1 Department of Medical and Biological Sciences, The Catholic University of Korea, Bucheon,
Gyeonggi, South Korea
2 Department of Biotechnology, The Catholic University of Korea, Bucheon, Gyeonggi, South Korea
3 Department of Pathology, Yale University School of Medicine, New Haven, Connecticut, United
States of America

Abstract

Glioblastoma is one of the most common primary malignant brain tumors with a
poor prognosis and high mortality rate. Since only small lipophilic molecules can
penetrate the blood–brain barrier, chemotherapy and immunotherapy are limited
in their ability to effectively treat brain tumors. 3D bioprinting has the potential
to directly model the 3D environment of human pathology and diseases. In many
cancers, 3D bioprinting technology closely mimics the tumor microenvironment,
making it a promising tool for drug screening and uncovering the mechanisms of
† These authors contributed equally cancer initiation and progression. Recent 3D bioprinting technologies have been
to this work. developed to recreate the dynamic interactions between the tumor and endothelial
*Corresponding author: cells. Brain tumor models using 3D bioprinting technology can reconstruct the
Hyunho Yoon biophysical heterogeneity and immune interactions in the brain. These advanced
(hyoon@catholic.ac.kr) models regulate the organization of tumor structures for preclinical drug testing
Citation: Kim A, Mo K, and reveal the immunological pathways involved in brain tumors. Here, we highlight
Choe S, Shin M, Yoon H. 3D bioprinting technologies that can replace conventional in vitro models for brain
Comprehensive insight tumor treatment.
into 3D bioprinting technology
for brain tumor modeling.
Int J Bioprint. 2024;10(6):4166.
doi: 10.36922/ijb.4166 Keywords: 3D Bioprinting; Blood–brain barrier; Glioblastoma; Glioblasto-
ma-on-a-chip; Tumor microenvironment
Received: July 8, 2024
1st revised: August 8, 2024
2nd revised: August 21, 2024
Accepted: August 22, 2024
Published Online: August 27, 2024 1. Introduction
Copyright: © 2024 Author(s).
This is an Open Access article Brain tumors remain one of the most complicated tumors, accounting for 85–90%
distributed under the terms of the of primary central nervous system (CNS) tumors. Although brain tumors have
1
Creative Commons Attribution various subtypes according to cell origin, their characteristics and prognosis are
License, permitting distribution,
and reproduction in any medium, distinguished. Some types of brain tumors, such as glioblastoma (GBM) and diffuse
provided the original work is intrinsic pontine glioma (DIPG), have a 5-year survival rate of only 30% following
properly cited. diagnosis. GBM is the most common and aggressive malignant primary brain tumor
2
3
Publisher’s Note: AccScience in adults, increasing after the age of 40 years and peaking at 75–84 years. Despite
Publishing remains neutral with the struggles for new therapeutic strategies, including radiotherapy, chemotherapy,
regard to jurisdictional claims in
published maps and institutional and surgery, GBM remains highly resistant to treatment, with poor survival rates. The
affiliations. most frequently used treatment for GBM is the Stupp regimen, which is a combination

Volume 10 Issue 6 (2024) 154 doi: 10.36922/ijb.4166