Page 82 - IJB-7-2

A Scientometric Analysis
A

B

C D

Figure 9. Correlation maps showing the interconnections of hydrogels for bioink formulations in (A) (i) all hydrogel blends, (ii) most
frequent interconnections in all hydrogel blends; (B) two-hydrogel blends, (C) three-hydrogel blends, and (D) four-hydrogel blends.

file (Supplementary Figures S1‑S4). Incorporating RGD chemical [125,204] , electrical [205,206] , and topological [207,208]
domains to promote cell adhesion is the most popular cues). In this category, the most popular choice was
functionalization strategy in this category [199,200] . The silicate nanoparticles. These nanoparticles are versatile,
use of growth factors [121,195] , and especially VEGF [201-203] , commercially available in a wide range of sizes at a
is also a frequent strategy for enhancing the biological relatively low cost, cytocompatible, and amenable to
performance of bioinks. functionalization with basic chemistry methods [209-216] .
From the pool of articles analyzed, 18 incorporated Bioink formulations can also be designed to
nano- or micro-particles into their bioink formulations for function as controlled-release matrices for drugs [198,244] .
different purposes (i.e., to enhance rheological properties, From the pool analyzed, seven reports incorporated
immobilize functional molecules, and/or provide different drugs for different aims, from modeling a drug-

78 International Journal of Bioprinting (2021)–Volume 7, Issue 2