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A Dual-Sensitive Hydrogel for 3D Printing
It is a challenge to print intricate 3D architectures of subsequent two layers was observed in the side view.
of a soft hydrogel due to the lack of mechanical strength. Then, a more complicated pyramid (20 × 20 × 10 mm )
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To demonstrate the inks’ ability to print centimeter-scale was printed without collapsing (Figure 5B). At last, a
objects with high shape fidelity, a variety of constructs self-supporting anatomical-size human nose (18 × 28 ×
were printed. The printing was carried out using DA 40 10 mm ) was printed (Figure 5C). The printed construct
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with the optimized printing parameters. First, we printed a showed high structural similarity to its 3D digital model
cuboid with the dimension of 20 × 20× 4 mm , the pictures in details, and no collapse was observed throughout the
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in Figure 5A revealed high shape retention. And fusion experiment.

A

B
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Figure 4. Printing of the dual-sensitive hydrogels inks. (A) Images of printed grids with DA00, DA20, DA40, DA60, DA60, and DA100
(scale bars in top view: 5 mm, in local view: 1 mm). Images of printed structures with DA40 using (B) different nozzle size and (C) different
filament interval (scale bars: 1 mm). (D) Line width of DA00, DA20, DA40, DA60, DA60, and DA100 in printed lattices. (E) Line
width of DA40 in printed lattices with different needle size. (F) Diffusion rate of DA40 in printed lattices with different filament interval.
(G) Photograph of printed strand on a construct with pillars. (H) Photograph of a printed multi-layers construct moved by hands.

148 International Journal of Bioprinting (2021)–Volume 7, Issue 3