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Topology Optimized Locking Compression Plates to Minimize Stress Shielding
           modifications (e.g. lattice structure, internal hollow, or porous   min Z ρ   f ⋅ u
                                                                                          T
                                                                                  ( ) =
           structures) [10,11] .  However,  the  fabrication  of  functionally      e                     (2.3)
           graded structures is complex and expensive, while design                    N
                                                                                            v ≤
           modifications usually require laborious and costly iterative            V = ∑ ρ ee  V ,
           steps  performed  by  expert  technicians.  Recently,  we         st . .    e= 1              (2.3a)
                                                                                
           proposed a novel design method to minimize stress shielding           ρ =  0  1 ,    or  e = 1,… , ,N
                                                                                  e
           using  topology  optimization  (TO) .  Results-focused on   where V is the initial volume and v  is volume of
                                       [12]
           two-dimensional (2D) topologies, considering tensile loads   each element.             e
           on the plates, loads on the holes simulating the screw and   The Solid Isotropic Microstructure with Penalization
           combination of both, and a maximum volume reduction of
           75%. The approach allowed to obtain designs of lightweight   (SIMP), a gradient-based TO approach, was considered to
                                                                                   . SIMP forces the design variable,
                                                               solve the TO problem
                                                                                [13,14]
           plates  with  reduced  equivalent  stiffness  compared  to   to have a penalized continuous convergence as follows:
           the  proposed  original  design  domains.  In  this  paper,  we               1
           extended the study to three-dimensional (3D) topologies,          0 < ρ ≤ρ ≤                   (2.4)
                                                                                      e
                                                                                  0
           investigating the use of 3D TO to redesign novel LCPs to          E (x,y,z   ρ  (x,y,z  p  i
           minimize the stress shielding phenomenon.  Three initial                 ) [=       )] E⋅      (2.5)
           plate designs with different screw hole numbers (four-, six-,             N  p
           and eight-hole plates) were redesigned considering different      K ( ) ρ= ∑ ρ ⋅ K e           (2.6)
                                                                                       e
           loading conditions (compression, bending, torsion, and                   e 1 =
           a combination of these loads) imposing different volume   where ρ is the non-zero minimum density, p is the
                                                                          0
           reductions  to  the  initial  designs  (25,  45,  and  75%).  The   penalization  factor  (recommended  to  have  a  value  of
                                                                                              i
           effect of mesh density on the TO is also investigated and   three for a better convergence), and E  is the initial Elastic
           discussed.  Topology-optimized plate design considering   modulus at ρ=1 of the material.
           bending load presented bending elastic modulus equivalent   Therefore, SIMP solves equation (2.3) as follows:
           to native bone.                                                   min          T
                                                                                   ( ) =
           2. TO                                                              ρ e   Z ρ e  f ⋅ u          (2.7)
           TO is an automatic iterative design technique to obtain            N
           optimal structural topologies based  on  the user-defined          ∑ (ρ e )v ≤ V ,
                                                                                      e
                                                                            
           loading and boundary conditions. The goal is to achieve            e= 1
                                                                              N
                                                                            
           a  design  with  an  optimal  material  distribution  (Ω*)      . st ∑ (ρ p )K u =  , f  (2.7a) (2.7b) (2.7c)
           from  an  initially  given  design  domain  (Ω),  which  is           e   e
           discretized into number of finite elements (N). The aim           e= 1
           was to redesign the domain by minimizing compliance                0 ρ <  0  ρ ≤  e  ≤  1,
           (maximizing stiffness):                                          
                                                                                
                                     T
                                min f  u              (2.1)       The iterative steps to achieve optimality through TO
                                  e ρ ,u                       are shown in Figure 1. The solution starts with the given
               where u is the displacement vectors and f is load   design domain, Ω, comprising the user-defined material
           vectors governed by:                                being discretized into a set of finite elements, with each
                                       N                       element  consisting  of a  density  value  contributing  to
                          f =  Kk e    ∑   K e ()k e  (2.2)   the overall design density. Then, sensitivity breakdown
                               ( ) u =
                                       e= 1                    is  defined  across  the  displacement  field  according  to
               where  K  is  the  global  stiffness  matrix,  K  is the   the loading and boundary conditions, which means that
                                                    e
           matrices of the element stiffness, and k is the stiffness of   the density is updated toward optimality, satisfying the
                                           e
           each element.                                       objective function and constraints in each iteration.
               The density (ρ) is considered as a function to modify   The  first  step  in  each  computational  iteration
           the  design’s  stiffness  matrix  and  treated  as  a  design   corresponds to the calculation of element  sensitivity
           variable. Therefore, the density imposed on each element   based on deriving Eq. 2.7 in respect to the density:
           (ρ )  of  the  design  domain  follows  a  binary  variation       ∂ Z     p    T
                                                                                             k
             e
           resulting in either ρ =1 (i.e., keeping the element) or ρ =0      ∂ ρ  = −  ρ p  [ ] u  [ ][ ] u  (2.8)
                                                                                              e
                                                        e
                           e
           (i.e., removing the element) values. Solving this problem           e      e
           through mathematical programming algorithms require     Sensitivity  filtering  determines  the  element
           the rewriting of optimization problem (2.1) as follows:  distribution passing through filtering formulas (e.g., mesh-
           154                         International Journal of Bioprinting (2021)–Volume 7, Issue 3
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