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3D Bioprinting Photo-crosslinkable Hydrogels for Bone and Cartilage Repair

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Figure 4. Construction of 3D mimetic osteochondral tissue by 3D bioprinting. (A) Schematic diagram of the biohybrid gradient scaffolds
for osteochondral regeneration. (B) Mechanical properties of poly (nacryloyl 2-glycine) -GelMA hydrogels: (i) tensile strength and
(ii) compressive strength. (C) Genetic analysis for osteochondral differentiation: (i and ii) Expression of cartilage-related genes (COL II,
aggrecan, SOX-9, and COL I) and (iii-iv) expression of osteogenesis-related genes (ALP, OCN, COL I, and RUNX2) after 7 and 14 days of
culture, respectively (from ref. licensed under Creative Commons Attribution 4.0 license).
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research. One of the primary transfer sites for breast metastasis study through 3D bioprinting . In their early
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carcinoma is bone; however, the fundamental mechanisms study, the authors printed the 3D bone matrix using a
are still unknown because of the lack of 3D biomimetic nano-bioink consisting of Hap and PEGDA (Mn 700)
models for cancer research. Therefore, Zhu et al. created hydrogel with 0.5% photo-initiator (Figure 5B). Results
a series of 3D bionic bone models for breast cancer bone indicated that the cocultivation of tumor cells and BMSCs

46 International Journal of Bioprinting (2021)–Volume 7, Issue 3