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Figure 5. Construction of 3D bioprinted hydrogels in bone disease model. (A) Fabrication of a musculoskeletal interface model: (i) Schematic
diagram of a native insertion site; (ii) illustration of the printing model; (iii) a representative image showing the bioprinted structure;
(iv) fluorescent image of the bioprinted structure; blue: osteoblasts, red: MSCs, and green: Fibroblasts . (Reproduced from A. K. Miri, D.
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Nieto, L. Iglesias, et al., Microfluidics-Enabled Multimaterial Maskless Stereolithographic Bioprinting from Wiley. © 2018 WILEY-VCH
Verlag GmbH Co. KgaA Weinheim). (B) Illustration of 3D bioprinted PEGDA bone matrix model for breast cancer cell invasion research .
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(Reprinted from Nanomed-Nanotechnol,12(1), W. Zhu, B. Holmes, R. I. Glazer, et al., 3D Printed Nanocomposite Matrix for The Study of
Breast Cancer Bone Metastasis, 69 – 79, Copyright (2016), with permission from Elsevier). (C) Schematic diagram of 3D bioprinted GelMA
bone matrix model for breast cancer metastasis study . (Reprinted with permission from X. Zhou, W. Zhu, M. Nowicki, et al., Acs Appl
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Mater Inter, 2016, 8(44): 30017 – 30026, Copyright (2016) American Chemical Society).

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