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Li, et al.
with better properties. Collectively, SOPL, a compelling http://doi.org/10.1002/adfm.202006839
and suitable approach, overcomes the limitations of 2. Li X, Huang X, Mo J, et al., 2021, A Fully Integrated
speed, volume, and quality in HMNP fabrication. With Closed-Loop System Based on Mesoporous Microneedles-
the development of materials and technology, SOPL Iontophoresis for Diabetes Treatment. Adv Sci (Weinh),
technology could promote the effective clinical translation
and commercialization of HMNP. 8:e2100827.
http://doi.org/10.1002/advs.202100827
5. Conclusions 3. Yao S, Wang Y, Chi J, et al., 2021, Porous MOF Microneedle

In summary, this study innovatively used SOPL technology Array Patch with Photothermal Responsive Nitric Oxide
for fast customization of HMNPs with high quality. An Delivery for Wound Healing. Adv Sci (Weinh), 9:e2103449.
HMNP could be obtained by one-step photopolymerization http://doi.org/10.1002/advs.202103449
within 5 s. The obtained HMNs had good biocompatibility, 4. Sadeqi A, Kiaee G, Zeng W, et al., 2022, Hard Polymeric
mechanical properties, and puncture performance. After Porous Microneedles on Stretchable Substrate for
being equipped with syringes, HMNPs could be used
for minimally invasive and painless injection of insulin Transdermal Drug Delivery. Sci Rep, 12:1853.
to control blood glucose levels. Collectively, SOPL http://doi.org/10.1038/s41598-022-05912-6
technology is expected to provide technical support for the 5. Economidou SN, Uddin MJ, Marques MJ, et al., 2021, A Novel
mass production of HMNPs and promote their widespread 3D Printed Hollow Microneedle Microelectromechanical
clinical application. System for Controlled, Personalized Transdermal Drug

Acknowledgments Delivery. Addit Manuf, 38:101815.
http://doi.org/10.1016/j.addma.2020.101815
We thank H. Wang from the Analytical and Testing Center, 6. Mishra R, Maiti TK, Bhattacharyya TK, 2019, Feasibility
Sichuan University, P. R. China for the SEM observation
and analysis of the data. We thank Zhiyuan Gou for his Studies on Nafion Membrane Actuated Micropump Integrated
help in the preparation of the HMN syringe. We also With Hollow Microneedles for Insulin Delivery Device.
thank Xide Dai for his work in the simulation video for J Microelectromech Syst, 28:987–96.
the visualization of the HMN formation process. http://doi.org/10.1109/Jmems.2019.2939189
Funding 7. Niu L, Chu LY, Burton SA, et al., 2019, Intradermal Delivery
of Vaccine Nanoparticles Using Hollow Microneedle Array
This research was funded by National Key Research and Generates Enhanced and Balanced Immune Response.
Development Program of China (2021YFF1200800), J. Control Release, 294:268–78.
Sichuan Innovative Research Team Program for Young
Scientists (2021JDTD0001), 1·3·5 project for disciplines http://doi.org/10.1016/j.jconrel.2018.12.026
of excellence, West China Hospital, Sichuan University 8. van der Maaden K, Heuts J, Camps M, et al., 2018, Hollow
(ZYJC18017, ZYYC08007). Microneedle-mediated Micro-injections of a Liposomal
HPV E743-63 Synthetic Long Peptide Vaccine for Efficient
Conflict of interest Induction of Cytotoxic and T-helper Responses. J Control
No conflict of interest was reported by all authors. Release, 269:347–54.

Author contributions http://doi.org/10.1016/j.jconrel.2017.11.035
9. Gupta J, Denson DD, Felner EI, et al., 2012, Rapid
The manuscript was written through contributions of Local Anesthesia in Humans Using Minimally Invasive
all authors. All authors have given approval to the final Microneedles. Clin J Pain, 28:129–35.
version of the manuscript. M.G. and Xian.J. designed and http://doi.org/10.1097/AJP.0b013e318225dbe9
supervised the project. R.L., X.L., and B.L. contributed to
experiment design and results. R.L., X.L., X.Y., S.W., L.L., 10. Dardano P, De Martino S, Battisti M, et al., 2021, One-Shot
Xue.J. and B.L. performed experiments. R.L., X.J., X.Y., Fabrication of Polymeric Hollow Microneedles by Standard
S.W., L.L. and Xue.J. wrote the manuscript. Photolithography. Polymers (Basel), 13:520.

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