Page 217 - IJB-9-1

International Journal of Bioprinting FeS /PCL scaffold for bone regeneration
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and proliferation of endothelial cells, resulting in vessel Author contributions
formation. The new vessels supply nutrients and oxygen Project administration: Donggu Kang, Hojun Jeon,
essential for the recruitment of progenitor MSCs to induce SangHyun An
osteogenesis. Moreover, the differentiation of the recruited Investigation – animal tests: Yoon Bum Lee, KyungHo Lee,
osteoprogenitors into osteoblasts relies on BMP-2, which is Kil Soo Kim
expressed by endothelial cells. The differentiated cells also Investigation – in vitro tests: Eunjeong Choi, Yoonju Nam,
secrete angiogenic factors, such as VEGF, to further regulate Jeong-Seok Lee
neovascularization. This cycle progresses throughout the Writing – original draft: Donggu Kang, Gi Hoon Yang
bone formation process. In short, there was an upregulation Writing – review & editing: Donggu Kang, Gi Hoon Yang
of new bone formation and neovascularization when FeS Formal analysis: Gi Hoon Yang, Yoon Bum Lee, Donggu Kang
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particles were embedded in PCL scaffolds. Therefore, we Visualization: Gi Hoon Yang, Yoon Bum Lee, Donggu Kang
assume that the increased compressive modulus due to the Methodology: MyungGu Yeo, Gil-Sang Yoon
incorporation of FeS significantly influenced the healing Software: Gi Hoon Yang, Yoon Bum Lee, Donggu Kang
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process at the bone defect site.
Funding acquisition: Hojun Jeon, SangHyun An,
4. Conclusion Kil Soo Kim
Composite scaffolds composed of PCL and FeS particles Ethics approval and consent to participate
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were developed using a 3D bioprinting system for bone
tissue regeneration. The fabricated scaffolds showed This animal study was approved by the local animal ethics
enhanced physical and biological properties, depending on committee (approval number: DGMIF-20100801-00).
the FeS content. A significant increase in surface roughness Consent for publication
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and compressive strength was observed in a dose-dependent
manner. Additionally, the in vivo results revealed enhanced Not applicable.
neovascularization and bone formation with increasing FeS
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content. Our study demonstrated the potential osteogenic Availability of data
effect of FeS for the first time in a rat calvarial defect model. Not applicable.
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However, hitherto the osteogenic efficacy of FeS is still not
2
well-established. Therefore, further studies are required to References
provide detailed analyses of the efficacy of FeS which could
2
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fragility and antiosteoporotic drug effects. Bonekey Rep, 2: 447.
Acknowledgments
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Conflict of interest 8. LaPrade RF, Botker JC, 2004, Donor-site morbidity after
osteochondral autograft transfer procedures. Arthrosc
The authors declare that they have no competing interests. J Arthrosc Relat Surg, 20(7): e69–e73.

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Volume 9 Issue 1 (2023)olume 9 Issue 1 (2023) 209 https://doi.org/10.18063/ijb.v9i1.636