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International Journal of Bioprinting


                                        RESEARCH ARTICLE
                                        Domain expert evaluation of advanced visual

                                        computing solutions and 3D printing for the
                                        planning of the left atrial appendage occluder

                                        interventions



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                                        Jordi Mill , Helena Montoliu , Abdel H. Moustafa , Andy L. Olivares ,
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                                        Carlos Albors , Ainhoa M. Aguado , Elodie Medina , Mario Ceresa ,
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                                        Xavier Freixa , Dabit Arzamendi , Hubert Cochet , Oscar Camara *
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                                        1 Physense, BCN Medtech, Department of Information and Communication Technologies, Universitat
                                        Pompeu Fabra, Barcelona, 08018 Spain
                                        2 Department of Cardiology, Hospital de la Santa Creu i Sant Pau, Barcelona, 08025, Spain
                                        3 Department of Cardiology, Hospital Clinic de Barcelona, 08036, Spain
                                        4 IHU Liryc, CHU Bordeaux, Université Bordeaux, Inserm 1045, Pessac, France
                                        Abstract
                                        Advanced visual computing solutions and three-dimensional (3D) printing are
                                        moving from engineering to clinical pipelines for training, planning, and guidance
                                        of complex interventions. 3D imaging and rendering, virtual reality (VR), and in-silico
            *Corresponding author:      simulations, as well as 3D printing technologies provide complementary information
            Oscar Camara                to better understand the structure and function of the organs, thereby improving
            (oscar.camara@upf.edu)      and personalizing clinical decisions. In this study, we evaluated several advanced
            Citation: Mill J, Montoliu H,   visual computing solutions, such as web-based 3D imaging visualization, VR, and
            Moustafa AH, et al., 2023, Domain   computational fluid simulations, together with 3D printing, for the planning of the
            expert evaluation of advanced   left atrial appendage occluder (LAAO) device implantations. Six cardiologists tested
            visual computing solutions and
            3D printing for the planning of the   different technologies in pre-operative data of five patients to identify the usability,
            left atrial appendage occluder   limitations, and requirements for the clinical translation of each technology through
            interventions. Int J Bioprint,   a qualitative questionnaire. The obtained results demonstrate the potential impact
            9(1): 640.
            https://doi.org/10.18063/ijb.v9i1.640  of advanced visual computing solutions and 3D printing to improve the planning of
                                        LAAO interventions as well as the need for their integration into a single workflow to
            Received: May 4, 2022
                                        be used in a clinical environment.
            Accepted: July 30, 2022
            Published Online: November 14,   Keywords: 3D printing; In silico simulations; Left atrial appendage occlusion; Pre-
            2022
                                        interventional planning; Virtual reality
            Copyright: © 2022 Author(s).
            This is an Open Access article
            distributed under the terms of the
            Creative Commons Attribution
            License, permitting distribution,   1. Introduction
            and reproduction in any medium,
            provided the original work is   Computing solutions, such as three-dimensional (3D) imaging and visualization, virtual/
            properly cited.             augmented reality (VR/AR), in silico simulations, and visual analytics, among others,
            Publisher’s Note: Whioce    have seen an outstanding progress in recent years. Advances and improved access to big
            Publishing remains neutral with   and high-resolution data, hardware infrastructure (e.g., high-performance computing
            regard to jurisdictional claims in
            published maps and institutional   clusters and graphical processing units), affordable devices (e.g., VR/AR headsets), and
            affiliations.               open-source codes thanks to the commitment to open and reproducible science by


            Volume 9 Issue 1 (2023)                        258                      https://doi.org/10.18063/ijb.v9i1.640
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