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International Journal of Bioprinting                          Micro/nano-3D hemostats for rapid wound healing






































































            Figure 2. Effects of structural modulation on cell behavior and response. (A) Micropillar arrays of different diameters and morphologies affecting cell
            adhesion and actin orientation [6,141] . (B) Chitosan-based porous wound dressing with excellent hemostatic properties . (C) Hemostatic evaluation of a
                                                                                       [51]
            CNF gauze .
                   [37]
            hemostatic response . Nanotopographical cues are   behavior. One example of the topographic modifications
                             [58]
            among the most critical factors which help to mediate   on the nanoscopic scale comes from a study by Nouri-
            cell adhesion, mainly through the interactions between   Goushki  et  al. .  This  study  revealed  that  the  design  of
                                                                           [6]
            proteins and ECM . Thus, controlling these interactions   specific 3D-printed surface-modified surface grooves
                           [18]
            via topographical features can synergistically improve cell   and nanopatterns directly affects cell adhesion forces,
            Volume 9 Issue 1 (2023)olume 9 Issue 1 (2023)
            V                                              359                      https://doi.org/10.18063/ijb.v9i1.648
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