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International Journal of Bioprinting                 Zn-doped coatings with osteogenic and antibacterial properties


            properties. Taken together, the multilayer coatings   bone tissue regeneration. Acta Biomater, 8: 3191–3200.
            prepared by layer-by-layer method could realize the      https://doi.org/10.1016/j.actbio.2012.06.014
            controllable release of Zn  and balance the osteogenic and
                                2+
            antimicrobial activity, indicating its promising potential in   3.   Arrigoni C, Gilardi M, Bersini S, et al., 2017, Bioprinting and
            bone tissue engineering.                              organ-on-chip applications towards personalized medicine
                                                                  for bone diseases. Stem Cell Rev Rep, 13: 407–417.
            Acknowledgments                                       https://doi.org/10.1007/s12015-017-9741-5
            The authors extend their sincere gratitude to those who   4.   Koons GL, Diba M, Mikos AG, 2020, Materials design for
            contributed in instructions and experiments.          bone-tissue engineering. Nat Rev Mater, 5: 584–603.
                                                                  https://doi.org/10.1038/s41578-020-0204-2
            Funding
                                                               5.   Garcia P, Histing T, Holstein JH, et al., 2013, Rodent animal
            This work was supported by Jiangsu Provincial Key     models of delayed bone healing and non-union formation:
            Research and Development Program (No. BE2019002).     A comprehensive review. Eur Cells Mater, 26: 1–12.

            Conflict of interest                                  https://doi.org/10.22203/ecm.v026a01
                                                               6.   Turnbull G, Clarke J, Picard F,  et al., 2018, 3D bioactive
            The authors declare that they have no known competing   composite scaffolds for bone tissue engineering.  Bioact
            financial interests or personal relationships that could have   Mater, 3: 278–314.
            appeared to influence the work reported in this paper.
                                                                  https://doi.org/10.1016/j.bioactmat.2017.10.001
            Author contributions                               7.   Aulakh TS, Jayasekera N, Kuiper JH,  et al., 2009, Long-
            Conceptualization: Zhijing He, Lida Shen              term clinical outcomes following the use of synthetic
            Data curation: Chen Jiao                              hydroxyapatite and bone graft in impaction in revision hip
                                                                  arthroplasty. Biomaterials, 30: 1732–1738.
            Formal analysis: Zongjun Tian
            Investigation: Changjiang Wang, Qing Jiang            https://doi.org/10.1016/j.biomaterials.2008.12.035
            Methodology: Zhijing He, Junnan Wu, Jiasen Gu, Huixin   8.   Jeong J, Kim JH, Shim JH, et al., 2019, Bioactive calcium
               Liang                                              phosphate materials and applications in bone regeneration.
            Supervision: Lida Shen, Zongjun Tian                  Biomater Res, 23: 4.
            Project administration: Lida Shen                     https://doi.org/10.1186/s40824-018-0149-3
            Validation: Zhijing He, Chen Jiao, Youwen Yang,
               Changjiang Wang                                 9.   Zeng JH, Liu SW, Xiong  L,  et al., 2018, Scaffolds for the
            Visualization: Chen Jiao                              repair of bone defects in clinical studies: A  systematic
                                                                  review. J Orthop Surg Res, 13: 33.
            Writing – original draft: Zhijing He
            Writing – review & editing: Youwen Yang               https://doi.org/10.1186/s13018-018-0724-2

            Ethics approval and consent to participate         10.  Mahanty A, Shikha D, 2022, Changes in the morphology,
                                                                  mechanical strength and biocompatibility of polymer and
            Not applicable.                                       metal/polymer fabricated hydroxyapatite for orthopaedic
                                                                  implants: A review. J Polym Eng, 42: 298–322.
            Consent for publication                               https://doi.org/10.1515/polyeng-2021-0171
            Not applicable.                                    11.  Vilardell  AM,  Cinca  N,  Concustell  A,  et al.,  2015,  Cold
                                                                  spray as an emerging technology for biocompatible and
            Availability of data                                  antibacterial coatings: State of art. J Mater Sci, 50: 4441–4462.
            The datasets used and analyzed during the present study      https://doi.org/10.1007/s10853-015-9013-1
            can be obtained from the corresponding author on request.
                                                               12.  Przekora A, 2019, Current trends in fabrication of
            References                                            biomaterials for bone and cartilage regeneration: Materials
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                                                               13.  Li F, Li S, Liu Y, et al., 2022, Current advances in the roles of
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                                                                  doped bioactive metal in biodegradable polymer composite
            2.   Ferreira AM, Gentile P, Chiono V, et al., 2012, Collagen for   scaffolds for bone repair: A  mini review.  Adv Eng Mater,


            Volume 9 Issue 2 (2023)                        303                      https://doi.org/10.18063/ijb.v9i2.668
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