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International Journal of Bioprinting Bioprinting of DNA hydrogels for bone organoids

DNA hydrogel is an excellent extracellular matrix, and Ethics approval and consent to participate
3D bioprinting of the hydrogel can generate a complex Not applicable.
bioactive scaffold that mimics the sophisticated micro–
nano structure of the bone tissue. Meanwhile, multiple cells Consent for publication
can be loaded in the printed DNA hydrogel, which is highly
promising for the construction of the bone organoids. Not applicable.
Based on the promising results in tissue engineering and
the advantages of the 3D bioprinting, we believe that the Availability of data
DNA hydrogels made by light-based 3D printing would be Not applicable.
a potential next-generation matrix gel for the construction
of bone organoids. References

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3D-printed DNA hydrogels only represent the tip of an 5. Mo X, Ouyang L, Xiong Z, et al., 2022, Advances in digital
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of shape, size, and pattern, could be more varied in terms 6. Mo F, Jiang K, Zhao D, et al., 2021, DNA hydrogel-based
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Acknowledgments 8. Qi H, Ghodousi M, Du Y, et al., 2013, DNA-directed self-
assembly of shape-controlled hydrogels. Nat Commun,
Not applicable. 4(1):1–10.
9. Lee JB, Peng S, Yang D, et al., 2012, A mechanical
Funding metamaterial made from a DNA hydrogel. Nat Nanotechnol,
This work was jointly supported by the National Natural 7(12):816–820.
Science Foundation of China (No. 82230071, 81901898), the 10. Brown TE, Anseth KS, 2017, Spatiotemporal hydrogel
China Postdoctoral Science Foundation (No. 2019M661404, biomaterials for regenerative medicine. Chem Soc Rev,
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11. Xue X, Hu Y, Deng Y, et al., 2021, Recent advances in design
Conflict of interest of functional biocompatible hydrogels for bone tissue
The authors declare no conflicts of interest. engineering. Adv Funct Mater, 31(19):2009432.
12. Xue X, Hu Y, Wang S, et al., 2022, Fabrication of physical and
Author contributions chemical crosslinked hydrogels for bone tissue engineering.
Bioact Mater, 12:327–339.
Conceptualization: Jiacan Su
Writing – original draft: Long Bai, Mengmeng Li 13. Nagahara S, Matsuda T, 1996, Hydrogel formation via
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Volume 9 Issue 2 (2023) 436 https://doi.org/10.18063/ijb.688