Page 68 - IJB-9-2

International Journal of Bioprinting Bioprinting in wound dressing and healing

printed directly onto the wound, which is then left to epithelial re-formation process and shows extraordinary
allow the material to fuse repeatedly. During the printing potential for treating diabetic wounds.
process, no part of the printer directly interacted with 3.12. Film. This cluster contains two articles. A pectin-
the animal. The results showed that after 8 weeks of in based bioprinting ink was proposed by Andriotis et al.
[93]
situ printing, a fully differentiated epidermis could This ink forms a transparent film after drying and can
be seen, keratinocytes fully proliferated and covered rapidly decompose after contact with water. Rees et al.
[94]
the wound, and the dermis grew to the wound edge. prepared a transparent nanocellulose-based film that can
Handheld instruments were also developed with the hope provide a moist wound healing environment and form an
of translating biofabrication into the field of surgery. elastic gel with bioresponsive properties.
O’Connell et al. described a handheld bioproduction
[81]
tool called “biopen.” Cheng et al. also described a 3.13. Nanocomposite This cluster contains only one
[82]
handheld instrument to deliver fibronectin-containing review. Traditional hydrogels are less likely to be used
mesenchymal stem/stromal cells directly to the trauma directly in wound dressings and healing because of their
surface, improving re-epithelialization, dermal cell poor physical properties, and work to improve hydrogels
regeneration, and neovascularization. with nanoparticles is summarized by Barrett-Catton
et al. The composite hydrogels tend to exhibit superior
[95]
3.8. Biomaterial. The papers of this cluster mainly
emphasize the properties of different biomaterials. physical and biochemical properties.
For example, the paper by Ma et al. highlights the Figure 9 shows the frequency of occurrence between
[83]
vascularization-inducing function of strontium silicate keywords. The results in Figure 9 can verify the clustering
microcylinders. Ulusu et al. emphasize the thermal analysis results in the above. Since the application of
[84]
stability and fluidic properties of a polymeric biomaterial bioprinting in wound dressing and healing is a topic in tissue
called Caf1. Pitton et al. also highlighted the hydrofluidic engineering, both “tissue engineering” and “bioprinting/
[85]
properties of pectin-cellulose nanofibers. wound healing” have a high frequency of co-occurrence.
The assembly of scaffolds is also a very important direction
3.9. Scaffold. This cluster contains four different
scaffolds for tissue engineering. A thermosensitive in this topic, so “scaffolds” and “fabrication” also have a
high frequency of co-occurrence. Meanwhile, hydrogels
hydrogel was prepared by Boffito et al. Xia et al. are the most commonly used option in bioprinted wound
[86]
[87]
prepared a curcumin-incorporated gelatin methacryloyl dressings. Among them, chitosan is one of the most
hydrogel. A bioactive microgel was synthesized by de Rutte commonly used raw materials for making hydrogel.
et al. A biomaterial sheet was prepared by Cheng et al. [82]
[88]
3.10. Bioink. The silhouette value of this cluster is only 4. Conclusion and perspectives
0.764, which is the lowest among all clusters. It contains
four reviews and one research paper. Masri et al. Bioprinting is an important new technology in wound
[89]
presented a strategy for printability quality improvement dressing and healing. This bibliometric-based investigation
of bioprinting for skin regeneration and wound healing. provides a statistical summary of how the topic has evolved
Nie et al. provided a summary and outlook on the between 2011 and 2022. Bioprinting is a cost-effective and
[90]
bioassembly by microfluidics. Serban et al. presented efficient production method that helps address challenges
[91]
hyaluronic acid for 3D structural assembly. Wang et al. like high production costs and slowing profits in the
[27]
specifically presented extrusion-based bioprinting for skin repair material industry and develop products with
wound dressing and healing. better performance. Compared with traditional skin
tissue engineering technology, bioprinting technology can
3.11. Diabetic wound. The treatment of diabetic
wounds is also important for bioprinted skin dressings and locate cell precise and produce complex and controllable
structure. Based on the above analysis, the following
healing. The most frequently occurring keyword in this conclusions can be drawn:
cluster is diabetic wound. Wan et al. prepared a bilayer
[92]
skin scaffold using gelatin as the matrix material using 3D (i) Bioprinting for wound dressing and healing has
printing technology. The upper layer of the scaffold consisted been published since 2011 but has not attracted
of gelatin cryogel loaded with silver nanoparticles, and the much attention for a short period of time. This topic
lower layer consisted of printed gelatin scaffold loaded with gained traction in 2018 and has continued to grow
platelet-derived growth factor. The bilayer skin scaffold was in the following years. Based on the bibliometric
shown to promote granulation tissue formation, collagen analysis, this trend does not show signs of stagnation.
deposition, and neointima formation in a diabetic mouse Therefore, this topic will continue to be dynamic for
wound model. This bilayer skin scaffold accelerates the some time.

Volume 9 Issue 2 (2023) 60 http://doi.org/10.18063/ijb.v9i2.653