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International Journal of Bioprinting Flow performance of porous implants with different geometry

experimenting. Furthermore, different cells had different Research Funds for Central Public Welfare Research
growth conditions, which means that the boundary Institutes (118009001000160001).
conditions needed to be adjusted appropriately according
to the actual situation. The next study will continue Conflict of interest
searching the most suitable porous scaffolds for cells The authors declare no conflicts of interest.
in different growth environments. At last, mechanical
properties are another important index to evaluate the Author contributions
performance of porous implants [38,41,42] . Combined with
fluid properties, the effect of the mechanical properties Conceptualization: Zhuxun Tang, Jian Li
of porous scaffolds will be further investigated in future Funding acquisition: Jian Li, Yueting Zhou
works. Investigation: Zhuxun Tang, Jian Li
Writing – original draft: Zhuxun Tang, Jian Li
4. Conclusion Writing – review & editing: Zhuxun Tang, Jian Li, Lifang
Ma, Yueting Zhou
This study investigated the effects of line structure, surface
structure and volume structure on the properties of Ethics approval and consent to participate
implants at different porosity. According to the results,
the three structures showed some similar tendency: the Not applicable.
reduction of characteristic parameters resulted in higher
porosities, and with the increase of porosity, specific surface Consent for publication
area and average permeability increased, but surface Not applicable.
area, average velocity, and wall shear stress displayed
decreasing tendency, and the area with appropriate wall Availability of data
shear stress seemed increasing. Besides, volume structure
had the smallest specific surface area, uneven mass and Not applicable.
flow velocity distribution, and maximum permeability,
and surface structure had the highest tortuosity, and the References
most suitable surface shear stress region for cell growth.
These characteristics mean that volume structures have 1. Anselme K, 2000, Osteoblast adhesion on biomaterials.
better mass transfer performance, and surface structures Biomaterials, 21:667–681.
are conducive to cell adhesion. In addition, differences https://doi.org/10.1016/S0142-9612(99)00242-2
among these three structures due to pore morphology 2. Peltola SM, Melchels FPW, Grijpma DW, et al., 2008, A
have also been discussed. These findings could be used to review of rapid prototyping techniques for tissue engineering
quantitatively control the design of porous implants and purposes. Ann Med, 40:268–280.
predict their biological properties.
https://doi.org/10.1080/07853890701881788
Acknowledgments 3. Bobbert FSL, Lietaert K, Eftekhari AA, et al., 2017,
Additively manufactured metallic porous biomaterials based
We acknowledge the supports of the National Natural on minimal surfaces: A unique combination of topological,
Science Foundation of China, the China Scholarship mechanical, and mass transport properties. Acta Biomater,
Council (CSC), the Fundamental Research Funds for 53:572–584.
the Central Universities, and the Fundamental Research https://doi.org/10.1016/j.actbio.2017.02.024
Funds for Central Public Welfare Research Institutes, and
Interdisciplinary Team Funds of Beijing University of Posts 4. Kumar A, Mandal S, Barui S, et al., 2016, Low temperature
and Telecommunications. additive manufacturing of three dimensional scaffolds for
bone-tissue engineering applications: Processing related
challenges and property assessment. Mater Sci Eng R Rep,
Funding 103:1–39.
The research was partially supported by the National Natural https://doi.org/10.1016/j.mser.2016.01.001
Science Foundation of China (Nos. 52005120, 11972257, 5. Kelly CN, Miller AT, Hollister SJ, et al., 2018, Design and
11972257, and 11832014), the China Scholarship Council structure-function characterization of 3D printed synthetic
(CSC), the Fundamental Research Funds for the Central porous biomaterials for tissue engineering. Adv Healthc
Universities (22120180223), National Key R&D program Mater, 7:1701095.
of China (No. 2020YFC2005900), and the Fundamental
https://doi.org/10.1002/adhm.201701095

Volume 9 Issue 3 (2023) 170 https://doi.org/10.18063/ijb.700