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International Journal of Bioprinting Dual ions mixed GelMA for hair follicle regeneration

Figure 8. The blood flows at the wounds were measured by laser Doppler of animals. (A) Representative images of blood perfusion volume. The circle
represents the position of the material. (B) Quantitative analysis of blood flow. N = 3 for each group. *P < 0.05, **P < 0.01. All the analyses were performed
with two-way ANOVA. Scale bar = 1 cm.
the control group had the lowest intensity. Hydrocolloid 4. Discussion
and GelMA groups had the same perfusion level, which Most mammalian animals can achieve scar-free wound
was lower than GelMA-Zn/Si group. In the follow-up repair during their fetal development. However, the
study, four groups maintained low signal intensity for the ability frequently disappears after birth . Recent studies
[5]
coverage of neogenic epidermis, but GelMA-Zn/Si group reported that the adult wound tissues still have the
always had the highest level. In short, the results showed regenerative competence but the lack of regeneration
that GelMA-Zn/Si hydrogel can improve wound perfusion signals contributes to the failure of tissue regeneration.
after trauma, which is consistent with the results above.

Volume 9 Issue 3 (2023) 211 https://doi.org/10.18063/ijb.703