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International Journal of Bioprinting Dual ions mixed GelMA for hair follicle regeneration

Figure 7. The relative gene expression of wound tissue on the 14th day after various treatments. *P < 0.05, **P < 0.01, ****P < 0.0001. N = 3 for each group.
All the analyses were performed with one-way ANOVA.

neogenic vessels. More interestingly, GelMA group did not angiogenesis , and our results showed that GelMA-Zn/Si
[9]
have significantly higher expression of most of the targeted hydrogel group has the highest expression of angiogenesis-
genes, suggesting that the ions in the hydrogel may be related genes. Therefore, laser Doppler perfusion
the main effective factors in hair follicle regeneration and measurement (LDPM) was employed to measure wound
angiogenesis. perfusion recovery in the scope to evaluate physiological
and pharmacological changes of vascular function
3.8. Perfusion recovery in vivo . As shown in Figure 8, on 0 day, four groups had
[35]
Favorable blood perfusion contributes to wound healing the same perfusion. On the 7th day, GelMA-Zn/Si hydrogel
and tissue regeneration . Zn and Si ions can stimulate group presented with the richest blood flow signals, while
[34]

Volume 9 Issue 3 (2023) 210 https://doi.org/10.18063/ijb.703