Page 377 - IJB-9-5

International Journal of Bioprinting

RESEARCH ARTICLE
Photocurable 3D-printed PMBG/TCP biphasic

scaffold mimicking vasculature for bone
regeneration

Changru Zhang 1,2,3† , Ya Ren 1,2† , Weiqing Kong , Yihao Liu , Heyue Li ,
2
2,4
5
Han Yang , Bin Cai , Kerong Dai , Chengwei Wang *, Liang Tang *, Haoyi Niu *,
2
2
7
1,2
2
6
Jinwu Wang *
1,2
1 Southwest JiaoTong University College of Medicine, No. 111 North 1st Section of Second Ring
Road, Chengdu 610036, China
2 Shanghai Key Laboratory of Orthopaedic Implant, Department of Orthopaedic Surgery, Shanghai
Ninth People’s Hospital Affiliated Shanghai Jiao Tong University School of Medicine, 639 Zhizaoju
Rd, Shanghai 200011, China
3 Institute of Translational Medicine, Shanghai JiaoTong University, No. 800 Dongchuan Road,
Shanghai 200240, China
4 Department of Spinal Surgery, The Affiliated Hospital of Qingdao University, No. 59 Haier Road,
Qingdao, Shandong Province 266000, China
5
Shanghai Seventh People’s Hospital, Affiliated to Shanghai University of Traditional Chinese
Medicine, Obstetrics and Gynecology, No. 358 Datong Road, Shanghai 200137, China
† These authors contributed equally
to this work. 6 Department of Rehabilitation Medicine, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong
University School of Medicine, No. 500 Quxi Road, Shanghai 200011, China
*Corresponding authors:
Chengwei Wang 7 Department of Orthopedic Surgery, Tongren Hospital, Shanghai Jiao Tong University School of
(wangcw_1222@163.com) Medicine, No. 1111 XianXia Road, Shanghai 200336, China
Liang Tang
(hts03@126.com)
Haoyi Niu
(haoyiniu@163.com) Abstract
Jinwu Wang
(wangjw-team@shsmu.edu.cn) Mesoporous bioglass (MBG) with excellent osteointegration, osteoinduction, and
Citation: Zhang C, Ren Y, Kong W, biodegradability is a promising material for bone regeneration. However, its clinical
et al., 2023, Photocurable application is hindered by complex processing and a lack of personalization, low
3D-printed PMBG/TCP biphasic mechanical strength, and uncontrollable degradation rate. In this study, we developed
scaffold mimicking vasculature for
bone regeneration. Int J Bioprint, a double-bond-functionalized photocurable mesoporous bioglass (PMBG) sol that
9(5): 767. enabled ultrafast photopolymerization within 5 s. By further integrating nanosized
https://doi.org/10.18063/ijb.767 tricalcium phosphate (TCP) particles through three-dimensional (3D) printing
Received: March 9, 2023 technology, we fabricated personalized and highly porous PMBG/TCP biphasic
Accepted: April 17, 2023 scaffolds. The mechanical properties and degradation behavior of the scaffolds were
Published Online: June 2, 2023 regulated by varying the amount of TCP doping. In vitro and in vivo experiments
4-
Copyright: © 2023 Author(s). verified that PMBG/TCP scaffolds slowly released SiO and Ca , forming a
2+
4
This is an Open Access article vascularized bone regeneration microenvironment within the fully interconnected
distributed under the terms of the
Creative Commons Attribution pore channels of the scaffold. This microenvironment promoted angiogenesis and
License, permitting distribution, accelerated bone tissue regeneration. Overall, this work demonstrates the solution
and reproduction in any medium, to the problem of complex processing and lack of personalization in bioglass
provided the original work is
properly cited. scaffolds, and the developed PMBG/TCP biphasic scaffold is an ideal material for
bone regeneration applications with broad clinical prospects.
Publisher’s Note: Whioce
Publishing remains neutral with
regard to jurisdictional claims in
published maps and institutional Keywords: Photocurable mesoporous bioglass; Personalization; Bone repair;
affiliations. Angiogenesis

Volume 9 Issue 5 (2023) 369 https://doi.org/10.18063/ijb.767