Page 510 - IJB-9-6

International

Journal of Bioprinting

RESEARCH ARTICLE
Uncovering advances in final end-user

applications, user acceptability, quality assurance,
and digital technologies for 3D-printed oral drug

delivery systems

Veronica L. Rios-Mata , Marisela Rodriguez-Salvador , Jia An ,
1†
1†*
2
Chee Kai Chua , and Pedro F. Castillo-Valdez 1
2,3
1 Tecnologico de Monterrey, Escuela de Ingeniería y Ciencias, Monterrey, Nuevo León, México
2 Centre for Healthcare Education, Entrepreneurship and Research at SUTD (CHEERS), Singapore
University of Technology and Design, Singapore
3 Engineering Product Development, Singapore University of Technology and Design, Singapore

Abstract
The increasing demand for innovative drugs and personalized treatment is radically
changing the pharmaceutical industry, where significant efforts in research and
development (R&D) are taking place. Three-dimensional (3D) printing offers
interesting solutions for these demands, solving some of the limitations of current
manufacturing processes. 3D-printed oral drug delivery systems can improve the
† These authors contributed equally delivery of pharmaceutical substances in the body, and the dynamic interaction
to this work. between pharmaceutical ingredients, while providing personalized formulations,
*Corresponding author: geometries, sizes, controlled release rates, and increasing time in the gastrointestinal
Marisela Rodriguez-Salvador tract. Advances in 3D printing for oral drug delivery systems have been investigated in
(marisrod@tec.mx)
terms of processes, materials, and effects. However, it is important to also consider other
Citation: Rios-Mata VL, Rodriguez- topics, such as the specific needs of the users to enhance drugs acceptability, the quality
Salvador M, An J, et al., 2023,
Uncovering advances in final end- control processes due to the absence of approved guidelines, and the digitalization of
user applications, user acceptability, the industry to respond to future challenges of the digital era; nevertheless, there are no
quality assurance, and digital studies that comprise these elements. To fill this gap, the aim of this research is to identify
technologies for 3D-printed oral
drug delivery systems. Int J Bioprint, advances in terms of final end-user applications, quality assurance, user acceptability,
9(6): 1119. and digital technologies for 3D-printed oral drug delivery systems. To accomplish this,
https://doi.org/10.36922/ijb.1119 a competitive technology intelligence (CTI) methodology was applied, where scientific
Received: June 22, 2023 literature was retrieved from the Web of Science covering the period from January 1,
Accepted: July 31, 2023 1900, to May 1, 2023. For this task, a scientometric analysis was performed, and the
Published Online: September 8, main trends involving the previously mentioned elements were identified. In the first
2023
case, 3D-printed oral drug delivery systems are being designed for different purposes,
Copyright: © 2023 Author(s). including as anti-deterrent formulations to decrease the global problem of opioid abuse.
This is an Open Access article
distributed under the terms of the For quality assurance, the results demonstrated the implementation of approaches
Creative Commons Attribution like quality by design to increase the quality of the 3D-printed dosage forms. In the
License, permitting distribution, case of user acceptability, the interest in creating more attractive formulations was
and reproduction in any medium,
provided the original work is identified; for this, innovative technologies such as ColorJet 3D printing are being used.
properly cited. Lastly, regarding digital technologies, the importance of cyberattacks while sending
Publisher’s Note: AccScience the 3D-printed dosage form file to the 3D printer is highlighted; for this, cybersecurity
Publishing remains neutral with systems are being studied. The outcomes of this study can add value to researchers,
regard to jurisdictional claims in organizations, and investment firms interested in the R&D of novel and personalized
published maps and institutional
affiliations. treatments, and the areas of 3D printing, pharmaceutical, medical, and health.

Volume 9 Issue 6 (2023) 502 https://doi.org/10.36922/ijb.1119