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International Journal of Bioprinting High-performance SrCS scaffolds via vat photopolymerization
Figure 13. rBMSCs proliferation of composite bioceramics for 1 and 7 days with the control group and different SrCS-BTA components, determined via
CCK-8 assay (****p < 0.001, **p < 0.01, one-way ANOVA).
increased from 0.32 to 0.59 s , while the corresponding Overall, the strontium-doped calcium silicate scaffolds
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densification temperature decreased from 1270°C to fabricated by VPP demonstrated significantly improved
1175°C. This indicates that the SrCS scaffolds doped mechanical properties and tunable biodegradability, which
with BTA exhibit a better densification behavior at high will be extremely useful for repairing damaged large
temperatures. During high-temperature sintering, the new segmental bone defects.
CaTiO grains formed at the CaSiO grains boundaries and
3
3
acted as in situ nailing (known as the pinning effect) to Acknowledgments
intercept the crack propagation and hinder the movement The authors would like to thank the State Key Laboratory
of the grains. Consequently, the SrCS-40BTA scaffold of Materials Processing and Die & Mould Technology for
revealed a 296% higher compressive strength and elastic their assistance in SEM, XRD, and mechanical tests. The
modulus than that of the pure SrCS scaffold. Besides, the author would also like to thank the Huazhong University
energy absorption of the SrCS-40BTA scaffold increased by of Science & Technology Analytical & Testing Center for
460%. Furthermore, this pinning effect plays a continuous their assistance in ultraviolet light absorption and Fourier
role in the degradation process of composite scaffolds, transforms infrared spectrometer characterization.
resulting in long-lasting reliable mechanical properties.
Figure 14. Images of early attachment of rBMSCs analyzed by confocal microscopy (after 24 h culturing with extracts). (a) Merged images of DAPI and
phalloidin. (b) DAPI (blue). (c) Phalloidin (red).
Volume 9 Issue 6 (2023) 535 https://doi.org/10.36922/ijb.1233
