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A. Ebrahimzadeh, R. Khanduzi, A. Jajarmi / IJOCTA, Vol.15, No.2, pp.294-310 (2025)
cost-effectiveness metrics for the specific cases an- Conflict of interest
alyzed can be found in Table 5. The numbers in
The authors declare that they have no conflict of
this table show that the threefold optimal control interest regarding the publication of this article.
strategy works much better than the twofold con-
trol method at lowering the number of infected Author contributions
people. This supports our findings even more.
Conceptualization: Asiyeh Ebrahimzadeh
Formal analysis: Amin Jajarmi
5. Conclusions and future research Investigation: Raheleh Khanduzi
directions Methodology: Asiyeh Ebrahimzadeh, Raheleh
Khanduzi
This paper suggested a novel hybrid strategy, the
Software: Amin Jajarmi
collocation method with FBMO for OCP on a
Writing – original draft: Asiyeh Ebrahimzadeh,
multi-strain COVID-19 model. We used Laguerre
Raheleh Khanduzi
polynomials and their derivative operational ma-
Writing – review & editing: Amin Jajarmi
trices to run a collocation method on this OCP.
This turned the OCP into an NLP. Then, the Availability of data
NLP was solved using FBMO to determine the
representation of isolation, vaccination efficacy, Not applicable.
and treatment enhancement in conjunction with
the state functions of the multi-strain COVID- References
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Funding
8. Burgess DJ. Network effects of disease mutations.
This work has financial support of Farhangian Nat Rev Genet., 2015;16(6):317.
https://doi.org/10.1038/nrg3957
University (Contract No. 500.17474.120).
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