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Abtahi et al. | Journal of Clinical and Translational Research 2024; 10(2): 119-140 133
Table A3. (Continued)
Factors Data set Definition CVR CVR assessment (critical,
essential, or rejected)
Total bilirubin Bilirubin is produced in the hemolysis of RBCs [64]. 0 Essential
LDH LDH is an enzyme with increased levels of hemolysis, necrosis, pneumonia, and 0.4 Essential
acidosis [65].
CRP CRP is an indicator of infection and acute inflammation [66]. 0.4 Essential
PCT PCT is a protein that indicates bacterial infection and sepsis [67]. −0.4 Essential
Ferritin Ferritin is an iron-storage protein and an indicator of artery and inflammatory 0 Essential
diseases [68].
Cardiac biomarkers Cardiac troponin Cardiac troponin is the main marker for cardiac infarction [69] 0.4 Essential
and tests for the CK CK is an indicator of muscle, brain, and heart damage [60]. 0.2 Essential
cardiovascular D-dimers D-dimers are byproducts of a blood clot and can indicate thrombosis [70]. 0.6 Essential
system
Coagulation Anti-thrombin (AT) AT activity is measured to diagnose thrombotic disorders [71]. 0 Essential
screening APTT APTT evaluates the internal coagulation pathway [60]. 0 Essential
FDPs FDP measurements indicate fibrinolysis [60]. 0.2 Essential
Fibrinogen Fibrinogen is a preceding substance that transforms into fibrin [72]. 0.2 Essential
Other factors GFR Indicates the flow of plasma from the glomerulus into Bowman’s space in a 0.6 Essential
specific period [73].
Performance score APACHE and ANZROD are different types of illness prognostic scoring systems 0.2 Essential
(e.g., APACHE and in intensive care units [74].
ANZROD)
SpO at admission SpO at admission refers to the pulse oximetry-derived SpO in room air at the 0.8 Critical
2 2 2
first hospital admission [36].
SOFA score The SOFA score is used as a diagnostic indicator [75]. 0.6 Essential
CURB-65 score The CURB-65 score is a scoring system that plays a role in patient 0.6 Essential
mortality [76].
Blood pH The pH of blood refers to its acidity. The typical pH of blood in the arteries 0.4 Essential
ranges from 7.35 to 7.45.
PaO PaO refers to the partial pressure of oxygen. 1 Critical
2 2
Abbreviations: ALT: Alanine transaminase; ANZROD: Australian and New Zealand risk of death; APACHE: Acute physiology and chronic health evaluation; APTT: Activated partial
thromboplastin time; AST: Aspartate transaminase; AT: Anti-thrombin; BMI: Body mass index; CK: Creatine kinase; CKD: Chronic kidney disease; COPD: Chronic obstructive pulmonary
disease; Cr: Creatinine; CRP: C-reactive protein; CURB-65: Confusion, blood urea>42.8 mg/dL, RR>30/min, blood pressure<90/60 mmHg, age>65; CVD: Cardiovascular disease; CVR: Content
validity ratio; eGFR: Estimated glomerular filtration rate; FDP: Fibrin degradation product; GFR: Glomerular filtration rate; IL-6: Interleukin-6; LDH: Lactate dehydrogenase; PaO : Arterial
2
oxygen pressure; PCT: Procalcitonin; RBC: Red blood cell; RR: Respiratory rate; SOFA: Sequential organ failure assessment; SpO : Oxygen saturation; WBC: White blood cell.
2

DOI: https://doi.org/10.36922/jctr.22.00226