Page 43 - JCTR-10-2

Abtahi et al. | Journal of Clinical and Translational Research 2024; 10(2): 119-140 137
Table A6. The contributing factors in the clinical decision-making on discharging COVID-19 patients
Factors Data set Definition CVR CVR assessment
(critical, essential,
or rejected)
Demographics Age Age refers to the patient’s age based on the year. 0.2 Essential
and medical Sex Sex refers to the gender of the patient. −1 Rejected
history
BMI or obesity BMI is a measure of body fat based on height and weight that applies to adult men and 0.2 Essential
women.
History of diabetes Diabetes mellitus is a metabolic disorder characterized by elevated blood sugar levels 0.6 Essential
mellitus over a long period [48].
History of cancer or Cancer is the abnormal growth of cells. The term malignancy refers to the presence of 0.4 Essential
malignancy cancerous cells that can spread to other sites in the body [49,50].
History of any CVD CVD is any disease of the heart or any disorder associated with blood vessels [51]. 0.2 Essential
History of renal function CKD is the presence of kidney damage or an eGFR of < 60 mL/min per 1.73 m for 0.4 Essential
2
impairment or CKD more than 2 months [52].
History of respiratory The most common respiratory diseases include COPD, asthma, pneumonia, pulmonary 0.6 Essential
disease fibrosis, and lung cancer [53].
History of liver disease Liver/hepatic disease is a type of damage to or disease of the liver that can be chronic or 0.2 Essential
acute [54].
History of autoimmune An autoimmune disease refers to any condition in which the immune system mistakenly 0.2 Essential
disease attacks the body [55].
History of Immunosuppressive drugs are a type of drug that suppresses or reduces the strength of 0.6 Essential
immunosuppressive drug the body’s immune system [56].
use
History of hypertension Hypertension refers to high blood pressure, which increases the risk of heart disease, 0 Essential
stroke, and sometimes death [57].
Other chronic conditions Comorbidity is defined as the concurrence of more than one disorder in an individual [58]. 0.2 Essential
or co-morbidity
Signs and Fever Fever refers to a high body temperature (over 37.5°C [99.5°F]). 0.4 Essential
symptoms Fatigue Fatigue describes the feeling of tiredness or lack of energy. −0.4 Rejected
Myalgia and/or arthralgia Myalgia refers to pain in a muscle or group of muscles. Arthralgia refers to joint −0.8 Rejected
stiffness and pain.
Vomiting or nausea Vomiting refers to the excretion of gastric contents through the mouth. 0 Essential
Sore throat A sore throat is the feeling of pain or scratchiness in the throat. −1 Rejected
RR RR is one of the main vital signs, referring to the number of breaths a person takes per 1 Critical
minute
Body temperature at Body temperature at admission refers to the patient’s body temperature measurement −0.6 Rejected
admission during the first visit.
WBC count WBC/leukocyte count Leukocytes play a pivotal role in inflammation and infection [59]. 0.6 Essential
Neutrophil count Neutrophils are a type of WBC that increase in response to an acute infection [59]. 0 Essential
Lymphocyte count Lymphocytes are a type of WBC with an anti-infection ability and can respond to 0.6 Essential
specific microorganisms [59].
Eosinophil count Eosinophils are a type of WBC with a histamine-neutralizing effect [59]. −0.8 Rejected
Monocyte count Monocytes are a type of WBC that transform into macrophages, which play important −0.8 Rejected
roles in both innate and acquired immunities [59].
Thrombocyte count Thrombocytosis refers to a higher-than-normal platelet count. −0.2 Rejected
Basic metabolic BUN The nitrogen content of urea is a primary metabolite derived from dietary and tissue 0.4 Essential
panel proteins [60].
Cytokines IL-6 IL-6 is an inflammatory and acute phase response marker [61]. 0 Essential
TNF-alpha TNF-alpha is a proinflammatory pain-causing cytokine [78]. 0 Essential
IL-8 IL-8 is a neutrophil and T-cell chemoattractant [78]. −0.4 Rejected
Enzymes and Albumin Albumin is the most abundant protein in blood [60]. −0.6 Rejected
biomarkers
LDH LDH is an enzyme with increased levels of hemolysis, necrosis, pneumonia, and 0.4 Essential
acidosis [65].
CRP CRP is an indicator of infection and acute inflammation [66]. −0.2 Rejected
(Cont’d...)
DOI: https://doi.org/10.36922/jctr.22.00226