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134 Abtahi et al. | Journal of Clinical and Translational Research 2024; 10(2): 119-140
Table A4. The contributing factors in clinical decision-making on home isolation of COVID-19 patients
Factors Data set Definition CVR CVR assessment
(critical, essential,
or rejected)
Demographics and Age Age refers to the patient’s age based on the year. 0.6 Essential
medical history Sex Sex refers to the gender of the patient. −0.8 Rejected
BMI or obesity BMI is a measure of body fat based on height and weight that applies to adult 0.4 Essential
men and women.
History of diabetes mellitus Diabetes mellitus is a metabolic disorder characterized by elevated blood sugar 0.4 Essential
levels over a long period [48].
History of cancer or Cancer is the abnormal growth of cells. The term malignancy refers to the 0.4 Essential
malignancy presence of cancerous cells that can spread to other sites in the body [49,50].
History of any CVD CVD is any disease of the heart or any disorder associated with blood vessels [51]. 0.6 Essential
History of renal function CKD is the presence of kidney damage or an eGFR of < 60 mL/min per 1.73 m 0.2 Essential
2
impairment or CKD for more than 2 months [52].
History of respiratory disease The most common respiratory diseases include COPD, asthma, pneumonia, 0.6 Essential
pulmonary fibrosis, and lung cancer [53].
History of liver disease Liver/hepatic disease is a type of damage to or disease of the liver that can be 0.2 Essential
chronic or acute [54].
History of autoimmune disease An autoimmune disease refers to any condition in which the immune system 0 Essential
mistakenly attacks the body [55].
History of immunosuppressive Immunosuppressive drugs are a type of drug that suppresses or reduces the 0.4 Essential
drug use strength of the body’s immune system [56].
History of hypertension Hypertension refers to high blood pressure, which increases the risk of heart −0.2 Rejected
disease, stroke, and sometimes death [57].
Other chronic conditions or Comorbidity is defined as the concurrence of more than one disorder in an 0.2 Essential
co-morbidity individual [58].
WBC count WBC/leukocyte count Leukocytes play a pivotal role in inflammation and infection [59]. 0.6 Essential
Lymphocyte count Lymphocytes are a type of WBC with an anti-infection ability and can respond to 0.4 Essential
specific microorganisms [59].
Basic metabolic Cr Cr is an indicator of kidney function [59]. 0.6 Essential
panel
Cytokines IL-6 IL-6 is an inflammatory and acute phase response marker [61]. 0 Essential
Enzymes and CRP CRP is an indicator of infection and acute inflammation [66]. 0.4 Essential
biomarkers PCT PCT is a protein that indicates bacterial infection and sepsis [67]. 0.2 Essential
Ferritin Ferritin is an iron-storage protein and an indicator of artery and inflammatory 0 Essential
diseases [68].
Cardiac biomarkers D-dimers D-dimers are byproducts of a blood clot and can indicate thrombosis [70]. 0.4 Essential
and tests for the
cardiovascular
system
Other factors GFR Indicates the flow of plasma from the glomerulus into Bowman’s space in a 0.6 Essential
specific period [73].
Performance score (e.g., APACHE and ANZROD are different types of illness prognostic scoring systems 0.6 Essential
APACHE and ANZROD) in intensive care units [74].
SpO 2 SpO is the percentage of oxygenated hemoglobin in a patient’s blood [77]. 1 Critical
2
Abbreviations: ANZROD: Australian and New Zealand Risk of Death; APACHE: Acute physiology and chronic health evaluation; BMI: Body mass index; CKD: Chronic kidney disease;
COPD: Chronic obstructive pulmonary disease; Cr: Creatinine; CRP: C-reactive protein; CVD: Cardiovascular disease; CVR: Content validity ratio; eGFR: Estimated glomerular filtration rate;
GFR: Glomerular filtration rate; IL-6: Interleukin-6; PCT: Procalcitonin; SpO : Oxygen saturation; WBC: White blood cell.
2

DOI: https://doi.org/10.36922/jctr.22.00226