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Abtahi et al. | Journal of Clinical and Translational Research 2024; 10(2): 119-140 139
Table A7. (Continued)
Factors Data set Definition CVR CVR assessment (critical,
essential, or rejected)
WBC count WBC/leukocyte count Leukocytes play a pivotal role in inflammation and infection [59]. 0.4 Essential
Neutrophil count Neutrophils are a type of WBC that increase in response to an acute 0 Essential
infection [59].
Lymphocyte count Lymphocytes are a type of WBC with an anti-infection ability and can 0.4 Essential
respond to specific microorganisms [59].
Eosinophil count Eosinophils are a type of WBC with a histamine-neutralizing effect [59]. −0.4 Rejected
Monocyte count Monocytes are a type of WBC that transform into macrophages, which -0.6 Rejected
play important roles in both innate and acquired immunities [59].
Basic metabolic Cr Cr is an indicator of kidney function [59]. 0.8 Critical
panel BUN The nitrogen content of urea is a primary metabolite derived from dietary 0 Essential
and tissue proteins [60].
Glucose Glucose has a six-carbon structure and is the main source of energy in the 0 Essential
body [60].
Cytokines IL-6 IL-6 is an inflammatory and acute phase response marker [61]. 0 Essential
CD8 cell count CD8 is a marker of cytotoxic T cells [59]. −0.4 Rejected
TNF-alpha TNF-alpha is a proinflammatory pain-causing cytokine [78]. −0.2 Rejected
IL-1 IL-1 is a costimulatory molecule in the acute phase response [78]. −0.6 Rejected
IL-2 IL-2 is involved in the proliferation of B-cells and activated T-cells [78]. −0.8 Rejected
IL-2R IL-2Rs are neoplasm, autoimmune disorder, and −0.8 Rejected
inflammation indicators [78].
IL-8 IL-8 is a neutrophil and T-cell chemoattractant [78]. −0.6 Rejected
IL-10 IL-10 is a cytokine production inhibitor [78]. −0.8 Rejected
Enzymes and Albumin Albumin is the most abundant protein in blood [60]. −0.4 Rejected
biomarkers AST AST is a good indicator of liver diseases, such as cirrhosis [62]. 0 Essential
ALT ALT is an indicator of liver diseases. It is a more specific marker of liver 0 Essential
diseases and infection than AST [63].
Total bilirubin Bilirubin is produced in the hemolysis of RBCs [64]. −0.4 Rejected
LDH LDH is an enzyme with increased levels of hemolysis, necrosis, 1 Critical
pneumonia, and acidosis [65].
Serum Cr A serum (blood) Cr test is a blood test used to evaluate the efficiency of 0.4 Essential
the kidney for blood filtration.
CRP CRP is an indicator of infection and acute inflammation [66]. 0.2 Essential
PCT PCT is a protein that indicates bacterial infection and sepsis [67]. −0.2 Rejected
Ferritin Ferritin is an iron-storage protein and an indicator of artery and −0.2 Rejected
inflammatory diseases [68].
Cardiac biomarkers Cardiac troponin Cardiac troponin is the main marker for cardiac infarction [69] 0.2 Essential
and tests for the CK CK is an indicator of muscle, brain, and heart damage [60]. −0.2 Rejected
cardiovascular D-dimers D-dimers are byproducts of a blood clot and can indicate thrombosis [70]. 0.2 Essential
system
Myoglobin Myoglobin is a muscle oxygen storage protein [80]. −0.4 Rejected
Coagulation AT AT activity is measured to diagnose thrombotic disorders [71]. −0.2 Rejected
screening PT PT measures the function of the external coagulation pathway [60]. −0.2 Rejected
APTT APTT evaluates the internal coagulation pathway [60]. −0.2 Rejected
FDPs FDP measurements indicate fibrinolysis [60]. −0.4 Rejected
Fibrinogen Fibrinogen is a preceding substance that transforms into fibrin [72]. −0.2 Rejected
Other factors GFR Indicates the flow of plasma from the glomerulus into Bowman’s space in 1 Critical
a specific period [73].
Performance score (e.g., APACHE and ANZROD are different types of illness prognostic scoring 0.2 Essential
APACHE and ANZROD) systems in ICUs [74].
SpO 2 SpO is the percentage of oxygenated hemoglobin in a patient’s blood [77]. 0.8 Critical
2
Sequential organ failure The SOFA score is used as a diagnostic indicator [75]. 0.4 Essential
assessment (SOFA) score
(Cont’d...)

DOI: https://doi.org/10.36922/jctr.22.00226