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Rando et al. | Journal of Clinical and Translational Research 2024; 10(3): 212-218 217
tethering that mimics the direction and magnitude of geometric Hearts. J Biomech Eng 2016;138:111006.
alterations observed in humans with FTR. This model offers a doi: 10.1115/1.4034621
simple, reproducible, and cost-effective option for testing and [6] Amini Khoiy K, Asgarian KT, Loth F, Amini R. Dilation
optimizing novel interventions for FTR before in vivo or clinical of Tricuspid Valve Annulus Immediately after Rupture
studies. of Chordae Tendineae in Ex-Vivo Porcine Hearts. PLoS

Acknowledgments One 2018;13:e0206744.
doi: 10.1371/journal.pone.0206744
None.
[7] Nguyen YN, Tay EL, Kabinejadian F, Ong CW, Ismail M,
Funding Leo HL. Ventricular Vortex Loss Analysis Due to Various
Tricuspid Valve Repair Techniques: An Ex Vivo Study.
This research was funded, in part, by the American Heart Am J Physiol Heart Circ Physiol 2019;317:H1312-27.
Association (Award #908805) and the American Association for doi: 10.1152/ajpheart.00150.2019
Thoracic Surgery Summer Intern Scholarship.
[8] Salurso E, Jaworek M, Perico F, Frigelli M, Romagnoni C,
Conflict of Interest Contino M, et al. Morphometric Characterization of
an Ex Vivo Porcine Model of Functional Tricuspid
The authors have no competing interests to disclose. Regurgitation. Ann Biomed Eng 2022;51:715-25.

Ethics Approval and Consent to Participate doi: 10.1007/s10439-022-03080-2
This study did not involve human subjects and was therefore [9] Pasrija C, Quinn R, Ghoreishi M, Eperjesi T, Lai E,
exempt from IRB approval. Gorman RC, et al. A Novel Quantitative Ex Vivo Model
of Functional Mitral Regurgitation. Innovations (Phila)
Consent for Publication 2020;15:329-37.
doi: 10.1177/1556984520930336
Not applicable.
[10] Crick SJ, Sheppard MN, Ho SY, Gebstein L, Anderson RH.
Availability of Data Anatomy of the pig Heart: Comparisons with Normal
Human Cardiac Structure. J Anat 1998;193:105-19.
Data are available from the corresponding author upon
reasonable request. doi: 10.1046/j.1469-7580.1998.19310105.x
[11] Karamali F, Hosseini S, Shojaeifard M, Mohammadi K,
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DOI: https://doi.org/10.36922/jctr.24.00003