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Tumor Discovery DRGs in HCC prognosis and immunity

Table 5. Detailed information on the correlation between six genes and sensitivity to drugs from the databases
Gene Drug Correlation coefficient False discovery rate Correlation
CAPZB Austocystin D −0.141087274 0.005804727 Sensitive
Pazopanib −0.173849265 0.000033753 Sensitive
Dasatinib −0.168540986 0.005699669 Sensitive
Compound 23 citrate 0.170831678 0.001937341 Resistance
Sotrastaurin 0.158002623 0.000105721 Resistance
Afatinib 0.123033433 0.0005555 Resistance
CD2AP Austocystin D −0.182505765 0.000015875 Sensitive
Lapatinib −0.110737669 0.009629998 Sensitive
Bosutinib −0.088728967 0.030302568 Sensitive
Afatinib −0.123312839 0.000537566 Sensitive
A-770041 −0.226790986 0.000493374 Sensitive
Kpt185 0.231873116 1.94179e-08 Resistance
Serdemetan 0.222105917 0.168597659 Resistance
Gw-843682x 0.217489267 2.2246e-08 Resistance
(5z)-7-oxozeaenol 0.186845876 2.26467e-07 Resistance
FLNA Tg×221 −0.323452482 4.56928e-09 Sensitive
Midostaurin −0.275955206 1.04e-13 Sensitive
17-AAG −0.284633046 5.11983e-16 Sensitive
Belinostat 0.401546268 7.8603e-15 Resistance
Pac-1 0.371434058 1.68066e-23 Resistance
Sr-ii-138a 0.36983117 8.11047e-26 Resistance
Wz3105 0.254281786 5.887e-14 Resistance
NCKAP1 17-AAG −0.344806738 1.00425e-23 Sensitive
Afatinib −0.201855734 4.40804E-09 Sensitive
Belinostat 0.445100924 2.73907e-18 Resistance
Lrrk2-in-1 0.422728526 2.33952e-23 Resistance
Ciclopirox 0.378017857 1.90393e-26 Resistance
Wz3105 0.431735223 0 Resistance
RPN1 Austocystin D −0.109550994 0.014444287 Sensitive
17-AAG −0.121562945 0.000916013 Sensitive
Pac-1 0.120091648 0.002415796 Resistance
Mitomycin 0.090786827 0.019872194 Resistance
Wz3105 0.114202068 0.001178826 Resistance
Temsirolimus 0.120785064 0.003797259 Resistance
SLC7A11 17-AAG −0.217447834 1.08873e-09 Sensitive
Kpt185 0.286751228 2.40003e-11 Resistance
Pac-1 0.270432867 1.06578e-12 Resistance
Ciclopirox 0.260975547 7.26742e-13 Resistance
(5z)-7-oxozeaenol 0.175243229 1.40465e-06 Resistance
Piperlongumine 0.189664289 3.33815e-07 Resistance

DGRs and immune checkpoints in HCC cell lines were in Huh7 and Hep3B cells than in normal hepatocyte cells,
further investigated in vitro. The results showed that the and no significant difference was observed in HepG2 cells.
mRNA expression levels of CAPZB and CD2AP were higher The mRNA expression levels of FLNA in the three HCC

Volume 4 Issue 2 (2025) 77 doi: 10.36922/td.8214