Page 88 - AIH-1-2

Artificial Intelligence in Health Combating XDR-bacteria as we approach 2050

Table 2. Multidrug‑resistant (mdr) genes in small and large plasmids
Accession number Size (kb) Multidrug‑resistant marker genes: Drug transporters GenBank (year) Pathogenic bacterial name
and antibiotic‑inactivating enzymes
KC543497 501 blaOXA-10, MFS, blaTEM-8, ble, catB8, and aac3’ 2014 P. aerogenosa
NC_018107 353 emrE, , crcB, NAT, terA/D, aph*, and blaTEM 2015 K. oxytoca
NC_022078 317 ABC, cat, aph*, aac3’, cmr, tetA, and blaKPC 2015 K. pneumoniae
MG252895 300 FloR, tetA, StrB/A, sul2, blaCMY/OXA/NDM, aac6’-Ib, 2020 E. coli
aphA7, arr2, cmlA1, aphA6, and sul1
LN555650 299 sul1, strA, catB, blaACC-1, aacA4, and blaVIM-1 2015 S. enterica
CP004000 295 bla HV-12, blaTEM-1, and ter C/A 2014 K. pneumoniae
S
CP007558 272 blaAmpC, ABC, sul1, blaTEM, aad, and ble 2014 C. freundii
JN420336 267 blaNDM1, blaOXA1, aac6’, qnrB1, cat, and blaCTX-M, 2020 K. pneumoniae
NC_014312 251 blaKPC2, mph 2, ABC, blaAmpC, and qnrB 2014 K. pneumoniae
AP012055 250 blaNDM , aadA2, catA1, and qacA1 2013 K. pneumoniae
1
KM877269 249 aad, floR, hph, aac6’/3’, , blaOXA-1, catB, arr3, and sul1 2015 S. enterica
CP011634 227 blaOXA, aad, blaTEM, aad, sul1, aac, and blaTEM 2015 K. oxytoca
HG530658 223 blaACC-1, strA, aadA2, aac3’, rcnA, and pcoS 2015 E. coli
NC_019375 180 blaVIM, aacA7, dhfr, ANT3’, SHV-5, sul1, and aph 3’ 2014 P. stuartii
JX442976 172 tetA, aph, sul2, aadA1, blaOXA-10, Qnr, and blaCMY-16 2013 K. pneumoniae
NC_022522 168 blaCTX-M25, aacA4*, strB, strA, aadB, and blaOXA-21 2014 S. enterica
NC_012692 167 strA, blaCMY2, groEL, stbA, strB, flo , and merA 2014 E. coli
R
LN850163 167 MFS, AAA tetA, cat, blaTEM, macB, and blaCTX-M 2015 E. coli
NC_019121 166 blaAmpC, sul2, tetA, flo , hygB , and aph 3’ 2014 S. enterica
R
R
LC055503 160 blaSHV12, aac6’, blaOXA10, aadA1, sul1, and blaDHA1 2015 K. pneumoniae
FJ628167 151 blaKPC, sul1, qnrB4, blaDHA, mph 2, and ABC 2010 K. pneumoniae
JX182975 289 Cat, aadA2, sul1, ble, blaNDM1, dhfr, mph 2, and acrA/F 2020 C. freundii
KT185451 151 blaTEM/CTXM/SHV12, blaKPC, and blaNDM1 2015 K. pneumoniae
KF250428 151 blaIMP-4, aacA4, cmr, and flo R 2013 K. pneumoniae
NC_012690 148 flo , tetA, strB, sul2, blaAmpC, sul1, aph, and blaTEM1, 2014 E. coli
R
AP012056 141 Aac3’/6’, catB4, tetA, sul2, blaOXA/CTX-M, and strB/A 2013 K. pneumoniae
KF954760 140 blaTEM1, strA, strB, and aadA 2014 K. pneumoniae
KP893385 137 blaCTXM-65, blaKPC-2, blaSHV-12, and blaTEM-1b 2015 K. pneumoniae
HG941719 135 aadA5, mph, blaCTXM/OXA/TEM, aac6’, sulI, and tetA 2014 E. coli
KF705205 134 hph, strA, aac3’-IV, tetA, and blaTEM-1 2015 S. enterica
NC_020087 133 aphA, hph, tetA, blaLAP , dhfr, ble, and qnrS1 2014 K. pneumoniae
2
CP009115 118 ble, blaOXA-1, qnr, and ble 2014 K. pneumoniae
GU256641 110 Sul2, strA, blaTEM1, blaSCO1, aacC2, and blaACC-4 2011 E. coli
NC_024978 110 dhfr, aad3, blaCTX , EtBr , and ABC-type 2014 E. coli
R
1
GU256641 110 Sul2, strA, blaTEM, blaSCO-1, aacC2, and blaACC-4 2011 E. coli
JX283456 108 blaKPC2, TolA, blaTEM, ABC transporter, and mph 2’, 2012 K. pneumoniae
JX566770 107 pac, aadA1, dhfrA1, strB, and blaTEM-1 2013 E. aerogenes
MF042358 100 Aac3’, ble, blaNDM-1, and sul1 2020 E. cloacae
CP009116 95 Aph, blaTEM, aac3’, MFS, dhfr, aad, arr2, and blaNDM1 2014 K. pneumoniae
NC_019889 87 Aac (3’)-II, blaNDM-1, sul1, MsrE, and mphE 2014 K. pneumoniae
KM406489 87 blaTEM-1 2015 S. marcescens
(Cont’d...)

Volume 1 Issue 2 (2024) 82 doi: 10.36922/aih.2284