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Artificial Intelligence in Health Combating XDR-bacteria as we approach 2050

A

B

C

D

Figure 25. Demonstration of mutacins homology, a pre-lantibiotic protein within the Streptococcus mutans plasmid (pUA140). This bacterium, notorious
for causing dental caries and oral cancer, utilizes lantibiotic to kill beneficial Lactobacillus bacteria. (A) Mutacin-I (strong homology); (B) Mutacin-II;
(C) Mutacin-SnbA; (D) another Mutacin-SnbA

Figure 26. Relationship between lantibiotic genes in oral bacteria, with 50% homology observed between Streptococcus salivarius and Lactobacillus lactis.
These enzymes are cloned, overexpressed, and utilized to develop cyclic peptide antibiotics in vitro. The medical AI technology is employed to formulate
unique salivaricin and lacticin-like antibiotics targeting membrane structures, inducing leakage of nutrients and subsequent death of extensively drug-
resistant bacteria

of these enzymes may lead to novel enzyme activity for the drugs and the ancient Indian herbal drug prescription,
development of novel lantibiotics against XDR-TB. 30 as documented in Sanskrit books such as the Charaka
India has the highest burden of TB, with one in every 550 Samhita, Susruta Samhita, and Atharva Veda, dating
people at risk of M. tuberculosis infection. We trust in herbal back 3000 years. 46,47 However, phytochemical purification

Volume 1 Issue 2 (2024) 90 doi: 10.36922/aih.2284