Page 90 - ARNM-3-1

Advances in Radiotherapy &

Nuclear Medicine

MINI-REVIEW
Nanostructured materials as potent platforms

for cancer chemoimmunotherapy

1,2
Himani Kalita * and Manoj Patowary 3
1 Department of Chemistry, Indian Institute of Technology Guwahati, Guwahati, Assam, India
2 Department of Chemistry, Savitribai Phule Pune University, Pune, Maharashtra, India
3 Department of Applied Sciences and Humanities, School of Computing, MIT Art, Design and
Technology University, Pune, Maharashtra, India

Abstract

Combinatorial chemoimmunotherapy has emerged as a potent approach in cancer
treatment, offering the advantages of combining two treatment strategies (i.e.,
chemotherapy and immunotherapy), thereby reducing drug dosages and improving
therapeutic outcomes. Nanomaterial-assisted drug delivery systems have garnered
significant attention in chemoimmunotherapy for encapsulating and delivering
therapeutic agents, as they can simultaneously target both cancer and immune
cells, promoting drug accumulation with excellent therapeutic efficacy and minimal
toxic side effects. This mini-review focuses on various aspects of immunotherapy
and chemoimmunotherapy in cancer treatment and discusses several nanomaterial-
assisted drug delivery systems used in chemoimmunotherapy.
*Corresponding author:
Himani Kalita
(hkalita74@gmail.com) Keywords: Chemoimmunotherapy; Immunotherapy; Cancer; Nanomaterial; Drug
Citation: Kalita H, Patowary M. delivery; Therapeutics
Nanostructured materials as
potent platforms for cancer
chemoimmunotherapy.
Adv Radiother Nucl Med.
2025;3(1):82-91. 1. Introduction
doi: 10.36922/arnm.8150
The immune system plays a crucial role in maintaining the body’s health by eliminating
Received: December 24, 2024 harmful pathogens and generating appropriate responses to infections. It primarily
Revised: January 16, 2025 functions by recognizing cell-surface pattern receptors, identifying pathogen-associated
molecular patterns in the microbes, and detecting damage-associated molecular
Accepted: February 3, 2025
patterns in injured tissues. Immunotherapy, therefore, stimulates white blood cells
1
Published online: February 18, to identify tumor tissues and offers a potent strategy for cancer management, which
2025
remains a critical global healthcare issue. While conventional cancer treatments, such
Copyright: © 2025 Author(s). as radiotherapy and chemotherapy, exhibit excellent tumoricidal capabilities, they often
This is an Open-Access article
distributed under the terms of the cause toxicity to both cancer and healthy cells, potentially leading to severe hematologic
Creative Commons Attribution toxicity and tissue dysfunction in patients. Cancer immunotherapy, on the other hand,
2
License, permitting distribution,
and reproduction in any medium, can specifically target tumor cells with mild side effects by leveraging the body’s immune
provided the original work is system to combat cancer. Furthermore, cancer immunotherapy has the potential to
properly cited. induce long-term antitumor responses in patients with advanced or metastatic cancers.
3
Publisher’s Note: AccScience Metastasis has become a major challenge in clinical cancer care and is believed to involve
Publishing remains neutral with a complex interplay between immune cells, cancer cells, and stromal cells at both the
regard to jurisdictional claims in 4
published maps and institutional primary and metastatic sites. Despite its advantages in specific tumor targeting with
affiliations. minimal side effects, immunotherapy faces several limitations, such as slow response,

Volume 3 Issue 1 (2025) 82 doi: 10.36922/arnm.8150