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Gene & Protein in Disease A pan-cancer analysis of HMGB1

Table 2. Expression/mutation of HMGB1 among different tumor types and its function
Cancer Gene expression Survival Genetic variation Protein phosphorylation Immune infiltration
types
CHOL ↑
COAD ↑
ESCA ↑
HNSC ↑ ↑ ↑
LIHC ↑
LUSC ↑
READ ↑
STAD ↑
BLCA ↑
GBM ↑
KIRC -- ↓
THCA --
PCPG --
CESC -- ↑
KICH ↓
LUAD ↓ ↑ ↓
PRAD ↓
DLBC ↑
LGG ↑
PAAD ↑
THYM ↑ ↓ ↓
OV ↑
BRCA ↓ ↓ ↑
UCEC ↓ ↓ ↓
ACC ↑
SARC ↑
MESO ↑
TGCT ↑
↑: Tumor-promoting effect; -- : Insignificant correlation; ↓: Tumor-suppressing effect.
CHOL: Cholangiocarcinoma; COAD: Colon adenocarcinoma; ESCA: Esophageal carcinoma; HNSC: Head and neck squamous cell carcinoma;
LUSC: Lung squamous cell carcinoma; STAD: Stomach adenocarcinoma; LIHC: Liver hepatocellular carcinoma; READ: Rectum adenocarcinoma;
BLCA: Bladder urothelial carcinoma; GBM: Glioblastoma multiforme; KIRC: Kidney renal clear cell carcinoma; CESC: Cervical squamous
cell carcinoma and endocervical adenocarcinoma; THCA: Thyroid carcinoma; PCPG: Pheochromocytoma and paraganglioma; KICH: Kidney
chromophobe; LUAD: Lung adenocarcinoma PRAD: Prostate adenocarcinoma; DLBC: Diffuse large B-cell lymphoma; LGG: Lower grade glioma
PAAD: Pancreatic adenocarcinoma; THYM: Thymoma; OV: Ovarian cancer; BRCA: Breast cancer; ACC: Adrenocortical carcinoma; UCEC: Uterine
corpus endometrial carcinoma; MESO: Mesothelioma; SARC: Sarcoma; TGCT: Testicular germ cell tumors

in different tumors may suggest different potential and THYM. This is similar to what other studies have
mechanisms and functions. We also found that high found . However, Huang et al. revealed that HMGB1
[34]
HMGB1 expression may predict the poor OS for patients overexpression was significantly correlated with poor
[35]
with ACC and LUAD. These results indicate that HMGB1 prognosis of patients with BLCA . These findings may
can be used as a biomarker to predict the prognosis of suggest that HMGB1 expression is not the same across
tumor patients. various kinds of tumors. Based on the characteristics
of each tumor, high or low expression of HMGB1 may
We discovered that the low expression of HMGB1 was provide a useful reference for the clinical treatment of
related to poor OS in some TCGA tumors, such as KIRC tumor patients.

Volume 2 Issue 1 (2023) 10 https://doi.org/10.36922/gpd.301