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Gene & Protein in Disease A pan-cancer analysis of HMGB1

As for lung cancer, our research found that high expression Conflict of interest
of HMGB1 was correlated with poor OS (P < 0.05), and poor
DFS (P < 0.05) in LUAD, but not in LUSC. In fact, many The authors declare that they have no competing interests.
studies have shown that HMGB1 can promote the occurrence, Author contributions
proliferation, and metastasis of lung cancer [36,37] , but the
molecular mechanism and signaling pathway involving Conceptualization: Hongnu Yu, Lin Wang
HMGB1 still need to be further clarified. Investigation: Wenqing Long, Jiaqi Li, Hao Shi, Lijun Zhang
Methodology: Wenqing Long, Jiaqi Li, Hao Shi, Lijun Zhang
Compared with the corresponding control tissues, Formal analysis: Wenqing Long
the total protein expression level of HMGB1 in BRCA Writing – original draft: Wenqing Long
tumor tissues was relatively lower. Studies have shown Writing – review & editing: Wenqing Long, Liqun Yang,
that HMGB1 has a close relationship with BRCA. The Zhuoyan Jiang, Lei Xia, Lin Wang, Hongnu Yu
majority of the BRCA studies have reported that HMGB1
can promote the migration and invasion of BRCA [38,39] . Ethics approval and consent to participate
MiR-142-3p can enhance the chemosensitivity of BRCA Not applicable.
and inhibit autophagy by targeting HMGB1 . Our findings
[40]
are contradictory to the literature reports. We consider that Consent for publication
these may be linked to the dual role of HMGB1 in tumors.
These results also indicate that HMGB1 may play a crucial Not applicable.
role in the treatment of BRCA. Availability of data
In addition to ACC and LUAD, our survival analysis
data also indicated that the high expression of HMGB1 in The datasets in this study are available in online repositories,
CESC, HNSC, and SARC was associated with poor DFS. TCGA datasets (https://www.cancer.gov/about-nci/organiza-
Li et al. and Xu et al. suggested that HMGB1 expression tion/ccg/research/structural-genomics/tcga), GTEx datasets
was a predictor of shorter OS and DFS in patients with (https://www.genome.go-v/Funded-Programs-Projects/
cervical cancer [41,42] . Liu et al. also indicated that HMGB1 Genotype-Tissue-Expression-Project), and GEO databases
was upregulated in human HNSC and overexpression (https://www.ncbi.nlm.nih.gov/geo/).
of HMGB1 was significantly related to the malignant References
progression and poor survival rate of HNSC patients,
suggesting that HMGB1 might be a potential therapeutic 1. Blum A, Wang P, Zenklusen JC, 2018, SnapShot: TCGA-
target of HNSC . Analyzed tumors. Cell, 173(2): 530.
[43]
In this study, our results showed that HMGB1 https://doi.org/10.1016/j.cell.2018.03.059
expression was positively correlated with the level of 2. Tomczak K, Czerwińska P,Wiznerowicz M, 2015, The
cancer-associated fibroblast immune infiltration in certain cancer genome atlas (TCGA): An immeasurable source of
tumors, including BRCA-LumA, TGCT, HNSC-HPV, and knowledge. Contemp Oncol (Pozn), 19(1a): A68–A77.
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MESO. Nevertheless, the relationship between HMGB1 https://doi.org/10.5114/wo.2014.47136
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3. Clough E, Barrett T, 2016, The gene expression omnibus
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Our pan-cancer analysis of HMGB1 demonstrates that the
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protein phosphorylation and immune cell infiltration in that encodes human high mobility group 1 protein (HMG1)
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to decipher the role of HMGB1 in tumorigenesis and to
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Funding
6. Li J, Kokkola R, Tabibzadeh S, et al., 2003, Structural basis
None. for the proinflammatory cytokine activity of high mobility

Volume 2 Issue 1 (2023) 11 https://doi.org/10.36922/gpd.301