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Gene & Protein in Disease MOR in cancer

Table 1. (Continued)
Tumors Drugs Effects Mechanism Signaling Result Conclusion References
(Opioids) pathway
Breast cancer Tumor Tumor Methylation OPCML was downregulated OPCML exerts tumor- [124]
promoter proliferation, of OPCML in most breast cancer suppressive effect in
migration, promoter samples but that this protein human breast cancer
and invasion was expressed in most cells, and the promoter-
adjacent non-tumor samples. specific hypermethylation
The loss or downregulation of OPCML plays an
of OPCML was associated important role in human
with hypermethylation of its breast cancer development
promoter
HNSCC No limits Tumor Tumor MOR is implicated in [108]
promoter proliferation, tumorigenesis of HNSCC.
migration, MOR could be used as a
and invasion potential therapeutic target
in patients with MOR (+)
HNSCC
CRC P-137 (a cyclic Tumor Anti- The activation of MOR [46]
morphiceptin suppressor inflammation might inhibit CRC
analog) progression
HCC Tumor Tumor MOR-NFAT MOR expression was MOR could be a novel and [125]
promoter proliferation positively related to HCC reliable HCSC marker and
and progression. Silencing MOR a potential therapeutic
migration greatly reduced HCC-related target against HCC via
tumorigenesis both in vitro MOR-NFAT signaling
and in vivo and significantly
extended the survival of
tumor-bearing mice
HCC Tumor High MOR expression in MOR has an [126]
promoter HCC tumors was correlated oncogenic function in
with poor prognosis. MOR hepatocarcinogenesis, and
inhibitors suppressed cell MOR inhibitors might be
growth, invasion, and a promising strategy for
metastasis HCC therapy
in vitro and in subcutaneous
and orthotopic xenograft
models
Breast cancer Morphine Tumor Tumor MAPK, – Clinical use of morphine [127]
promoter angiogenesis PKB/AKT could potentially be
harmful in patients with
angiogenesis-dependent
cancers
Breast cancer Morphine Tumor Morphine significantly Morphine might be unable [128]
suppressor reduced the cell vitality, to promote the progression
growth, and colony of cancer in breast
formation rate of MCF-7 cancer patients receiving
morphine analgesia
Breast cancer Morphine Tumor Tumor MAPK/ – Morphine promotes [47]
promoter angiogenesis ERK, PI3k/ angiogenesis and promotes
AKT, VEGF breast cancer progression
LLC Morphine Tumor Tumor HIF-1α/p38 – Morphine, in addition [129]
suppressor angiogenesis MAPK to its analgesic function,
can be exploited for its
antiangiogenic potential

(Cont’d....)

Volume 2 Issue 2 (2023) 7 https://doi.org/10.36922/gpd.282