Page 52 - GTM-2-2

Global Translational Medicine FTO gene and obesity

of the genotype with the BMI was observed in eight Belarusian Medical Academy of Postgraduate Education
polymorphic variants of the FTO gene: In the carriers of (protocol № 4 dated 04.12.2017).
minor homozygotes of polymorphic variants rs11075990,
rs1121980, rs1421085, rs17817449, rs3751812, rs9939609, Consent for publication
rs9940128, and rs9941349, the BMI was much higher All participants gave written informed consent to
compared with the carriers of corresponding major publishing their anonymized data.
homozygotes (P = 0.0022 – 0.021). Using the polymorphic
variant rs11075990 as an example, it was shown that Availability of data
FTO genotype frequencies correlate with BMI. Thus, the Data available on request from the corresponding author.
frequency of the A/A genotype in the studied groups
decreases with increasing BMI. Major A/A homozygote References
carriers are more likely to have normal weight compared
to heterozygotes and minor G/G homozygote carriers. An 1. Kopelman PG, 2000, Obesity as a medical problem. Nature,
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analysis of linkage disequilibrium of 13 polymorphic variants
of the FTO gene was carried out. It was found that the https://doi.org/10.1038/35007508
rs10852521 polymorphic variant is linked to the rs8047395 2. Peeters A, Barendregt JJ, Willekens F, et al., 2003, Obesity in
variant (r = 0.95) and rs1477196 to rs4783819 (r = 0.96), adulthood and its consequences for life expectancy: A life-
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polymorphic variants. Eight polymorphic variants of the https://doi.org/10.7326/0003-4819-138-1-200301070-00008
FTO gene for which a statistically significant association
with the BMI was shown constitute one block of linkage 3. World Health Organization. Overweight and Obesity
disequilibrium (r = 0.82 – 1.0, P < 0.001) and form two most Report Fact Sheet. Available from: https://www.who.int/
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news-room/fact-sheets/detail/obesity-and-overweight [Last
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C/G/T/A/A/T (42.8%). The frequency of occurrence of other
haplotypes does not exceed 2%. Therefore, to determine a 4. UNICEF, World Bank. Levels and Trends in Child
risk of obesity, carrying out genetic testing for one of these Malnutrition: UNICEF-WHO-World Bank Joint Child
polymorphic variants seems to be sufficient. Malnutrition. Available from: https://www.who.int/
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None.
science to weight management. Nutr Bull, 42: 246–253.
Funding https://doi.org/10.1111/nbu.12280

This research was funded by NATIONAL ACADEMY 6. Horowitz JF, Klein S, 2000, Lipid metabolism during
OF SCIENCES OF BELARUS, scientific and technical endurance exercise. Am J Clin Nutr, 72: 558–563.
program of the Union State “DNA-identification,” grant https://doi.org/10.1093/ajcn/72.2.558S
number 6.1.
7. Richter EA, Derave W, Wojtaszewski JF, 2001, Glucose,
Conflict of interest exercise and insulin: Emerging concepts. J Physiol,
535: 313–322.
The authors declare they have no competing interests. https://doi.org/10.1111/j.1469-7793.2001.t01-2-00313.x

Author contributions 8. Gerken T, Girard CA, Tung YC, et al., 2007, The obesity-
associated FTO gene encodes a 2-oxoglutarate-dependent
Conceptualization: Irma B. Mosse, Larisa I. Danilova nucleic acid demethylase. Science, 318: 1469–1472.
Investigation: Maxim D. Ameliyanovich, Maxim L. Lushchyk
Methodology: Larisa I. Danilova https://doi:10.1126/science.1151710
Writing – original draft: Irma B. Mosse 9. Han Z, Niu T, Chang J, et al., 2010, Crystal structure of the
Writing – review & drafting: Maxim D. Ameliyanovich FTO protein reveals basis for its substrate specificity. Nature,
464: 1205–1209.
Ethics approval and consent to participate https://doi.org/10.1038/nature08921
The informed consent form in accordance with the 10. Frayling TM, Timpson NJ, Weedon MN, et al., 2007, A
Declaration of Helsinki (as amended in 2013) and the study common variant in the FTO gene is associated with body
program were approved by the Bioethics Committee of the mass index and predisposes to childhood and adult obesity.

Volume 2 Issue 2 (2023) 8 https://doi.org/10.36922/gtm.352