Page 53 - GTM-2-2
P. 53
Global Translational Medicine FTO gene and obesity
Science, 316: 889–894. 19. Solé X, Guinó E, Valls J, et al., 2006, SNPStats: A web tool
for the analysis of association studies. Bioinformatics,
https://doi.org/10.1126/science.1141634
22: 1928–1929.
11. Dina C, Meyre D, Gallina S, et al., 2007, Variation in FTO https://doi.org/10.1093/bioinformatics/btl268
contributes to childhood obesity and severe adult obesity.
Nat Genet, 39: 724–726. 20. Dandine-Roulland C, Perdry H, 2018, Manipulation of
Genetic Data (SNPs). Computation of GRM and Dominance
https://doi.org/10.1038/ng2048
Matrix, LD, Heritability with Efficient Algorithms for Linear
12. Peng S, Zhu Y, Xu F, et al., 2011, FTO gene polymorphisms Mixed Model (AIREML). In: Proceedings of the Forty-Sixth
and obesity risk: A meta-analysis. BMC Med, 9: 71. European Mathematical Genetics Meeting, 2018. p. 6.
https://doi.org/10.1186/1741-7015-9-71 21. Tan LJ, Zhu H, He H, et al., 2014, Replication of 6 obesity
genes in a meta-analysis of genome-wide association studies
13. Scuteri A, Sanna S, Chen WM, et al., 2007, Genome-wide from diverse ancestries. PLoS One, 9: e96149.
association scan shows genetic variants in the FTO gene
are associated with obesity-related traits. PLoS Genet, https://doi.org/10.1371/journal.pone.0096149
3: 1200–1210. 22. Peters U, North KE, Sethupathy P, et al., 2013, A systematic
https://doi.org/10.1371/journal.pgen.0030115 mapping approach of 16q12.2/FTO and BMI in more than
20,000 African Americans narrows in on the underlying
14. Cornes BK, Lind PA, Medland SE, et al., 2009, Replication of functional variation: Results from the Population
the association of common rs9939609 variant of FTO with Architecture using Genomics and Epidemiology (PAGE)
increased BMI in an Australian adult twin population but study. PLoS Genet, 9: e1003171.
no evidence for gene by environment (G x E) interaction. Int
J Obes (Lond), 33: 75–79. https://doi.org/10.1371/journal.pgen.1003171
https://doi.org/10.1038/ijo.2008.223 23. Rampersaud E, Mitchell BD, Pollin TI, et al., 2008, Physical
activity and the association of common FTO gene variants
15. Tan JT, Dorajoo R, Seielstad M, et al., 2008, FTO variants with body mass index and obesity. Arch Intern Med,
are associated with obesity in the Chinese and Malay 168: 1791–1797.
populations in Singapore. Diabetes, 57: 2851–2857.
https://doi.org/10.1001/archinte.168.16.1791
https://doi.org/10.2337/db08-0214
24. Xu Y, Ling J, Yang M, et al., 2014, Rs7206790 and rs11644943
16. Freathy RM, Timpson NJ, Lawlor DA, et al., 2008, Common in FTO gene are associated with risk of obesity in Chinese
variation in the FTO gene alters diabetes-related metabolic school-age population. PLoS One, 9:e108050.
traits to the extent expected given its effect on BMI. Diabetes,
57: 1419–1426. https://doi.org/10.1371/journal.pone.0108050
25. Li, X., Mei, L., Yang, K., et al., 2009, Identifying association
https://doi.org/10.2337/db07-1466
under a previous linkage peak on chromosome 16 for body
17. Hinney A, Nguyen TT, Scherag A, et al., 2007, Genome wide mass index using cross-sectional and longitudinal data of
association (GWA) study for early onset extreme obesity the Framingham Heart Study. BMC Proc, 3: S101.
supports the role of fat mass and obesity associated gene
(FTO) variants. PLoS One, 2: e1361. https://doi.org/10.1186/1753-6561-3-s7-s101
26. Apalasamy YD, Ming MF, Rampal S, et al., 2012, Genetic
https://doi.org/10.1371/journal.pone.0001361
association of SNPs in the FTO gene and predisposition
18. Loos RJ, 2009, Recent progress in the genetics of common to obesity in Malaysian Malays. Braz J Med Biol Res,
obesity. Br J Clin Pharmacol, 68: 811–829. 45: 1119–1126.
https://doi.org/10.1111/j.1365-2125.2009.03523.x https://doi.org/10.1590/s0100-879x2012007500134
Volume 2 Issue 2 (2023) 9 https://doi.org/10.36922/gtm.352

