Page 75 - GTM-4-3

Global Translational Medicine Precision medicine via personalized nutrition

or tissue, with the aim of gaining insights into disease methodologies and integration of proteomic data into
mechanisms, discovering biomarkers for disease, and publicly accessible databases are beginning to address
pinpointing potential therapeutic targets for disease these challenges. With these advancements, the era of
prevention 36-38 (Figure 9). personalized, patient-tailored therapeutic strategies
is approaching. As a result, clinical and nutritional
Nutritional proteomics (Figure 10), also known as
nutriproteomics, leverages proteomic tools to analyze proteomics seek to apply the methodologies and principles
to the fields of PPM and PPM-guided PN and PF.
40
molecular and cellular changes in protein expression and
function while assessing how proteins interact with food Comprehensive protein profiles complement the
nutrients. It is essential to recognize that proteins specific genome by reflecting expression in specific cells or
41
to an organ, once released from damaged tissue, often organs, plasma, or serum, enabling the identification of
undergo degradation upon entering the bloodstream. In biomarkers that respond to dietary changes or treatment
addition, blood serum contains many proteins, including and potentially predicting biological processes. While
albumin, which has a broad dynamic range, making proteomics has yet to be widely adopted in nutritional
accurate quantification challenging. Variations in serum research, it offers advantages over transcriptome analysis,
protein levels can reflect shifts in the inflammatory as it directly examines the molecules responsible for
response, offering insights into the underlying pathological conducting biological functions. 42
process. Therefore, collecting organ-specific fluids such as In the food industry, proteomics-based techniques play
synovial fluid, urine, or spinal fluid near the affected tissue a critical role in ensuring food safety and authenticity.
may provide a more reliable source of potential diagnostic These methods are used to detect foodborne pathogens by
and therapeutic biomarkers than serum. Protein profiles analyzing variations in their proteome, identify allergens
have been shown to serve as valuable markers, capable and toxins, validate and optimize food processing, and
of predicting treatment outcomes for various diseases, pinpoint bioactive compounds in functional foods. In
including nutritional disorders. The standardization of addition, proteomics enables the authentication of meat and

Figure 9. The intersection of nutritional proteomics and disease prevention. Personalized nutrition is a powerful tool that enables consumers to improve
their dietary habits, optimize health, and prevent diet-related diseases. Omics technologies provide detailed insights into metabolic dynamics. However,
translating these insights into personalized, simple, and affordable nutrition protocols remains challenging due to the complexity of metabolism and
technical and economic limitations. Proteomics is essential to identify proteins that serve as biomarkers associated with disease progression. 38,39

Volume 4 Issue 3 (2025) 67 doi: 10.36922/GTM025080017