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International Journal of AI for
            Materials and Design                                          Optimization of membrane shrinkage and stability



            exhibited a slight increase. In Figure 8D, both %RD and   broader applications in smart material design and precision
            %TD elevated with increasing voltage, indicating voltage   fabrication.
            as a key parameter in shrinkage control. These results
            demonstrate that  meeting shrinkage targets alone is   Acknowledgments
            insufficient for ensuring process reliability. Incorporating   None.
            CIW as a stability metric allows selection of process
            conditions that are both accurate and robust, providing a   Funding
            practical basis for optimizing electrospinning parameters   This work was funded by the National Natural
            in scalable production.
                                                               Science Foundation of China (grant no.: 52031005,
              The machine  learning models in this study were   52571227), Natural Science Foundation of Shanghai
            developed and validated using experimental data from   (grant no.: 24ZR1438200), Shanghai Academy of
            controlled electrospinning trials of TPU membranes,   Spaceflight Technology  Joint Research  Fund (grant no.:
            with repeated measurements used to capture both mean   USCAST2023-19), Equipment Development Department
            shrinkage and variability via the CIW metric. Monte   Huiyan Action (grant no.: 5D3D1365), and China
            Carlo optimization was conducted on these validated   Scholarship Council (grant no.:202406230025).
            models within practical parameter ranges, ensuring
            physically relevant predictions. The modeling framework   Conflict of interest
            is material-agnostic and, in principle, applicable to other   The authors declare they have no competing interests.
            polymers; extending it requires retraining with high-
            quality data specific to the target material to capture   Author contributions
            its unique processing-structure-property relationships.
            Direct experimental validation of our multi-objective   Conceptualization: Wei Min Huang, Shiyu He
            optimization framework was not performed due to the   Formal analysis: Shiyu He, Li Cong Huang
            high cost and time required. Future work will address   Investigation: Shiyu He, Wei Min Huang, Fei Xiao
            this to further enhance the model’s robustness and   Methodology: Shiyu He, Chentong Gao, Runzhi Lu
            generalizability.                                  Writing–original draft: Shiyu He, Wei Min Huang
                                                               Writing–review & editing: Shiyu He, Wei Min Huang,
            4. Conclusion                                         Fei Xiao
            This paper presents a data-driven framework that   Ethics approval and consent to participate
            combines machine learning with Monte Carlo simulation
            to achieve accurate and stable control of biaxial shrinkage   Not applicable.
            in electrospun membranes, even under limited data   Consent for publication
            conditions.
                                                               Not applicable.
              By modeling shrinkage ratios in both RD and TD
            along with their stability, the framework enables multi-  Availability of data
            objective optimization of process parameters. Among the
            evaluated models, SVR demonstrated the highest accuracy   Data are available from the corresponding author upon
            in predicting shrinkage behavior, achieving an RMSE of   reasonable request.
            1.04% for RD and 2.00% for TD. XGBT was most effective   References
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            Volume 2 Issue 3 (2025)                         75                        doi: 10.36922/IJAMD025260022
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